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Next-Generation Seq...
Next-Generation Sequencing of Circulating Tumor DNA Can Optimize Second-Line Treatment in RAS Wild-Type Metastatic Colorectal Cancer after Progression on anti-EGFR Therapy : Time to Rethink Our Approach
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- Mauri, Davide (author)
- Department of Medical Oncology, University of Ιoannina, Ιoannina, Greece
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- Kamposioras, Konstantinos (author)
- Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK
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- Matthaios, Dimitrios (author)
- Department of Oncology, General Hospital of Rhodes, Rhodes, Greece
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- Tolia, Maria (author)
- Department of Radiotherapy/Radiation Oncology, Faculty of Medicine, University of Crete, Heraklion, Greece
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- Nixon, Ioanna (author)
- Scottish Sarcoma Network (SSN) UK Chair NCRI HN Epidemiology and Survivorship Subgroup, The Beatson West of Scotland Cancer Centre, Glasgow, UK
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- Dambrosio, Mario (author)
- Department of Medical Oncology, Clinica San Carlo, Paderno Dugnano, Italy
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- Zarkavelis, Georgios (author)
- Department of Medical Oncology, University of Ιoannina, Ιoannina, Greece
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- Papadimitriou, Konstantinos (author)
- University Hospital of Antwerp, Antwerp, Belgium
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- Petricevic, Branka (author)
- Department of Hematology and Oncology, Klinik Ottakring, Vienna, Austria
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- Kountourakis, Pantelis (author)
- Medical Oncology Department, Bank of Cyprus Oncology Centre, Nicosia, Cyprus
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- Kopecky, Jindrich (author)
- Department of Clinical Oncology and Radiotherapy, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
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- Kuhar, Cvetka Grašič (author)
- Department of Medical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
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- Popovic, Lazar (author)
- Medical Oncology Department, Oncology Institute of Vojvodina, University of Novi Sad, Novi Sad, Serbia
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- Chilingirova, Nataliya P. (author)
- Medical Oncology Clinic at Specialized Hospital for Active Treatment in Oncology, University Pleven, Sofia, Bulgaria
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- De Mello, Ramon Andrade (author)
- Department of Biomedical Sciences & Medicine, University of Algarve, Faro, Portugal; Precision Oncology Group, Federal University of São Paulo (UNIFESP), & Nine of July University (UNINOVE), São Paulo, Brazil
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- Plavetic, Natalija Dedic (author)
- Department of Oncology, University Hospital Centre Zagreb, University of Zagreb, School of Medicine, Zagreb, Croatia
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- Katsanos, Konstantinos (author)
- Department of Gastroenterology, University Hospital of Ioannina, Ιoannina, Greece
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- Mostert, Bianca (author)
- Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands
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- Alongi, Filippo (author)
- Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital, Cancer Care Center, Verona, Italy; University of Brescia, Brescia, Italy
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- de Bari, Berardino (author)
- Hospitalier Neuchâtelois, La Chaux-de-Fonds, Switzerland
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- Corradini, Stefanie (author)
- Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany
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- Kampletsas, Eleytherios (author)
- Department of Medical Oncology, University of Ιoannina, Ιoannina, Greece
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- Gazouli, Ioanna (author)
- Department of Medical Oncology, University of Ιoannina, Ιoannina, Greece
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- Gkoura, Stefania (author)
- Department of Medical Oncology, University of Ιoannina, Ιoannina, Greece
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- Amylidi, Anna-Lea (author)
- Department of Medical Oncology, University of Ιoannina, Ιoannina, Greece
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- Valachis, Antonis, 1984- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Oncology
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(creator_code:org_t)
- 2022-01-09
- 2022
- English.
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In: Oncology Research and Treatment. - : S. Karger. - 2296-5270 .- 2296-5262. ; 45:4, s. 216-220
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Management of Ras wild-type colorectal cancer (CRC) patients upon disease progression after the successful use of targeted treatment with anti-EGFR monoclonal antibodies and backbone chemotherapy remains a clinical challenge.Summary: Development of treatment resistance with prevalence of preexisting RAS mutated clones, RAS mutation conversion, truncation of extracellular receptor domains as well as HER2 and MET amplification are molecular events that can be difficult to follow without the use of sophisticated laboratory techniques. The clinical hurdle of re-biopsy and tumor heterogeneity can be overcome by the implementation of next-generation sequencing (NGS) to analyze circulating tumor DNA (ctDNA) and identify druggable mutations or recovery of RAS-wildness. In this opinion paper, we summarize with critical thinking the clinical approach to be followed after the failure of first-line treatment in Ras wild-type CRC tumors with the use of NGS. Rechallenge with anti-EGFR inhibitors, in case of persistent or recovery of RAS-wildness, and targeted approach of specific mutations (BRAF inhibitors), amplifications (anti-Her2 treatment), or fusion proteins (NTRK inhibitors) can by guided by the use of NGS. The use of NGS platforms for serial analysis of ctDNA is an important step to better understand the molecular landscape of metastatic CRC and guide clinical decisions.Key Messages: NGS should be considered a mainstay in clinical practice for the management of CRC patients and health authorities should consider reimbursing its use in the appropriate clinical settings.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Next-generation sequencing
- Circulating tumor DNA
- 2nd-line
- Targeted
- Treatments
- Metastatic colorectal carcinoma
- Progression
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Mauri, Davide
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Kamposioras, Kon ...
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Matthaios, Dimit ...
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Tolia, Maria
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Nixon, Ioanna
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Dambrosio, Mario
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Zarkavelis, Geor ...
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Papadimitriou, K ...
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Petricevic, Bran ...
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Kountourakis, Pa ...
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Kopecky, Jindric ...
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Kuhar, Cvetka Gr ...
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Popovic, Lazar
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Chilingirova, Na ...
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De Mello, Ramon ...
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Plavetic, Natali ...
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Katsanos, Konsta ...
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Mostert, Bianca
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Alongi, Filippo
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de Bari, Berardi ...
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Corradini, Stefa ...
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Kampletsas, Eley ...
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Gazouli, Ioanna
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Gkoura, Stefania
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Amylidi, Anna-Le ...
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Valachis, Antoni ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Oncology Researc ...
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Örebro University