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Downregulated Mucos...
Downregulated Mucosal Autophagy, Alpha Kinase-1 and IL-17 Signaling Pathways in Active and Quiescent Ulcerative Colitis
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- Moraes Holst, Luiza (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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- Halfvarson, Jonas, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology,Örebro Univ, Fac Med & Hlth, Dept Gastroenterol, Örebro, Sweden.
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- Carlson, Marie, 1957- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala Univ, Sweden
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- Hedin, Charlotte (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Stockholm, Sweden.
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- Kruse, Robert, 1972- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Research Laboratory,Örebro Univ, Fac Med & Hlth, Dept Clin Res Lab, Örebro, Sweden.
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- Lindqvist, Carl Mårten, 1979- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.
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- Bergemalm, Daniel, 1977- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology,Örebro Univ, Fac Med & Hlth, Dept Gastroenterol, Örebro, Sweden.
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- Almér, Sven (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Stockholm, Sweden.
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- Bresso, Francesca (author)
- Karolinska Institutet,Karolinska Univ Hosp, Dept Gastroenterol Dermatovenereol & Rheumatol, Gastroenterol Unit, Stockholm, Sweden.
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- Ling Lundström, Maria (author)
- Department of Medical Sciences, Uppsala University, Uppsala, Sweden,Uppsala Univ, Sweden
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- Repsilber, Dirk, 1971- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.
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- D'Amato, Mauro (author)
- Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain,Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.;Basque Fdn Sci, IKERBASQUE, Bilbao, Spain.;CIC bioGUNE BRTA, Gastrointestinal Genet Lab, Derio, Spain.
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- Keita, Åsa (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten
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- Hjortswang, Henrik (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken
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- Söderholm, Johan D (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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- Sundin, Johanna (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Sahlgrens Acad, Inst Med, Dept Internal Med & Clin Nutr, Gothenburg, Sweden.,Uppsala Univ, Sweden; Sahlgrens Acad, Sweden
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- Törnblom, Hans, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Simrén, Magnus, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Strid, Hans (author)
- Department of Internal Medicine, Södra Älvsborg Hospital, Borås, Sweden,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.;Sodra Alvsborg Hosp, Dept Internal Med, Borås, Sweden.
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- Magnusson, Maria K, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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- Öhman, Lena, 1967 (author)
- Gothenburg University,Göteborgs universitet,Uppsala universitet,Institutionen för medicinska vetenskaper,Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Microbiol & Immunol, Gothenburg, Sweden.;Karolinska Inst, Dept Med Solna, Stockholm, Sweden.;Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.;Karolinska Univ Hosp, Dept Gastroenterol Dermatovenereol & Rheumatol, Gastroenterol Unit, Stockholm, Sweden.,Univ Gothenburg, Sweden; Uppsala Univ, Sweden; Karolinska Inst, Sweden; Orebro Univ, Sweden; Karolinska Univ Hosp, Sweden,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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- Ling, Maria K. (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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(creator_code:org_t)
- DOVE MEDICAL PRESS LTD, 2022
- 2022
- English.
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In: Clinical and Experimental Gastroenterology. - : DOVE MEDICAL PRESS LTD. - 1178-7023. ; 15, s. 129-144
- Related links:
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https://doi.org/10.2...
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https://uu.diva-port... (primary) (Raw object)
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.2...
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http://kipublication...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Background: Improved mucosal immune profiling in active and quiescent colonic inflammatory bowel disease (IBD) is needed to develop therapeutic options for treating and preventing flares. This study therefore aimed to provide a comprehensive mucosal characterization with emphasis on immunological host response of patients with active ulcerative colitis (UC active), UC during remission (UC remission) and active colonic Crohn's disease (CD active).Methods: Colonic biopsies from 47 study subjects were collected for gene expression and pathway analyses using the NanoString host-response panel, including 776 genes and 56 immune-related pathways.Results: The majority of mucosal gene expression and signaling pathway scores were increased in active IBD (n=27) compared to healthy subjects (n=10). However, both active IBD and UC remission (n=10) demonstrated decreased gene expression and signaling pathway scores related to autophagy, alpha kinase-1 and IL-17 signaling pathways compared to healthy subjects. Further, UC remission was characterized by decreased scores of several signaling pathways linked to homeostasis along with increased mononuclear cell migration pathway score as compared to healthy subjects. No major differences in the colonic mucosal gene expression between CD active (n=7) and UC (n=20) active were observed.Conclusion: This study indicates that autophagy, alpha kinase-1 and IL-17 signaling pathways are persistently downregulated in UC irrespective of disease activity. Further, UC patients in remission present a unique mucosal environment, potentially preventing patients from reaching and sustaining true homeostasis. These findings may enable better comprehension of the remitting and relapsing pattern of colonic IBD and guide future treatment and prevention of flares.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Gene expression
- homeostasis
- host response
- inflammatory bowel diseases
- mucosal transcriptome
Publication and Content Type
- ref (subject category)
- art (subject category)
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Moraes Holst, Lu ...
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Halfvarson, Jona ...
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Carlson, Marie, ...
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Hedin, Charlotte
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Kruse, Robert, 1 ...
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Lindqvist, Carl ...
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Bergemalm, Danie ...
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Almér, Sven
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Bresso, Francesc ...
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Ling Lundström, ...
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Repsilber, Dirk, ...
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D'Amato, Mauro
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Keita, Åsa
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Hjortswang, Henr ...
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Söderholm, Johan ...
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Sundin, Johanna
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Törnblom, Hans, ...
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Simrén, Magnus, ...
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Strid, Hans
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Magnusson, Maria ...
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Öhman, Lena, 196 ...
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Ling, Maria K.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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Clinical and Exp ...
- By the university
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Örebro University
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Karolinska Institutet
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Uppsala University
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Linköping University
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University of Gothenburg