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Immunopsychiatry fr...
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Hylén, Ulrika,1977-Örebro universitet,Institutionen för medicinska vetenskaper
(author)
Immunopsychiatry from a transdiagnostic perspective : the immunometabolic interplay
Publisher, publication year, extent ...
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Örebro :Örebro University,2022
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129 s.
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-101094
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ISBN:9789175294674
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-101094URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:vet swepub-contenttype
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Subject category:dok swepub-publicationtype
Series
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Örebro Studies in Medicine,1652-4063 ;270
Notes
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Background/Objective: Psychiatric disorders are common and they significantly impact quality of life. It has been proposed that inflammatory processescontribute to the emergence of psychiatric disorders. In addition to inflammation, disturbances in metabolic pathways have been seen in individuals with various psychiatric disorders. At the interface between inflammation and metabolism stands the Nod-like receptor 3 (NLRP3) inflammasome, which is anintracellular protein complex responsible for cleaving members of the interleukin-1(IL-1) to their active forms. The overall aim of this thesis project was tounderstand the interplay between metabolism and inflammation in a transdiagnostic cohort of individuals with severe psychiatric disorders.Methods: Patients with severe psychiatric disorder (n=39) and age- and sexmatched healthy controls (n=39) were included in the studies. Psychiatric diagnoses, comorbidities, severity, and functioning were measured using a numberof validated assessment scales. Biological parameters, such as circulating immune markers, gene expression, and metabolites were analyzed using electrochemiluminescence immunoassay, qPCR, and UHPLC-MSMS, respectively. Results: The results revealed that in individuals with psychiatric disorders, immune cells were primed in regard to the NLRP3 inflammasome, with elevatedinflammasome-related cytokine levels, regardless of diagnosis. In addition, positive metabolic inflammasome regulators, such as lactic acid, serine, and glutamine were significantly higher in the patients; the main metabolic pathwaysthat were affected included arginine and proline metabolism and tryptophan metabolism. A number of these parameters also correlated with the patients’ disease severity. Lastly, the patients as a group displayed transdiagnosticchanges in immune–lipid pathways. In particular, strong associations could beobserved between two triglycerides and one ether phospholipid, with the inflammatory markers osteopontin and IL-1Ra.Conclusion: Severe psychiatric disorders are associated with changes in the inflammasome system and its corresponding cytokines, as well as with metabolicdysregulation. The data indicate that, while these systems are known to be associated, their interplay seems limited to relatively few inflammatory mediatorsand metabolites in this patient group. Lastly, while large overlaps were seen between different primary diagnoses, unifying, transdiagnostic patterns of inflammatory and metabolic dysregulation were weak; further studies with a largercohort are needed to examine this issue.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Bejerot, Susanne,professor,1955-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)sebt
(thesis advisor)
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Särndahl, Eva,professor,1963-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)easl
(thesis advisor)
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Eklund, Daniel,1984-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)ded
(thesis advisor)
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Lindqvist, Daniel,docentLunds universitet, Enheten för biologisk psykiatri och precisionspsykiatri, Lund
(opponent)
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Örebro universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
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