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Neither myonuclear ...
Neither myonuclear accretion nor a myonuclear domain size ceiling is a feature of the attenuated hypertrophic potential of aged human skeletal muscle
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- Brook, Matthew S (author)
- MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK; School of Life Sciences, University of Nottingham, Nottingham, UK
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- Wilkinson, Daniel J (author)
- MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK
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- Tarum, Janelle (author)
- School of Health Sciences, Örebro University, Örebro, Sweden
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- Mitchell, Kyle W (author)
- MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK
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- Lund, Jonathan L (author)
- MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK
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- Phillips, Bethan E (author)
- MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK
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- Szewczyk, Nathaniel J (author)
- MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK
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- Kadi, Fawzi, 1970- (author)
- Örebro universitet,Institutionen för hälsovetenskaper
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- Greenhaff, Paul L (author)
- MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK; School of Life Sciences, University of Nottingham, Nottingham, UK
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- Smith, Ken (author)
- MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK
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- Atherton, Philip J (author)
- MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology (COMAP), School of Medicine, University of Nottingham, Derby, UK
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(creator_code:org_t)
- 2022-09-09
- 2023
- English.
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In: GeroScience. - : Springer. - 2509-2715 .- 2509-2723. ; 45, s. 451-462
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Ageing limits growth capacity of skeletal muscle (e.g. in response to resistance exercise), but the role of satellite cell (SC) function in driving this phenomenon is poorly defined. Younger (Y) (~ 23 years) and older (O) men (~ 69 years) (normal-weight BMI) underwent 6 weeks of unilateral resistance exercise training (RET). Muscle biopsies were taken at baseline and after 3-/6-week training. We determined muscle size by fibre CSA (and type), SC number, myonuclei counts and DNA synthesis (via D2O ingestion). At baseline, there were no significant differences in fibre areas between Y and O. RET increased type I fibre area in Y from baseline at both 3 weeks and 6 weeks (baseline: 4509 ± 534 µm2, 3 weeks; 5497 ± 510 µm2 P < 0.05, 6 weeks; 5402 ± 352 µm2 P < 0.05), whilst O increased from baseline at 6 weeks only (baseline 5120 ± 403 µm2, 3 weeks; 5606 ± 620 µm2, 6 weeks; 6017 ± 482 µm2 P < 0.05). However, type II fibre area increased from baseline in Y at both 3 weeks and 6 weeks (baseline: 4949 ± 459 µm2, 3 weeks; 6145 ± 484 µm2 (P < 0.01), 6 weeks; 5992 ± 491 µm2 (P < 0.01), whilst O showed no change (baseline 5210 ± 410 µm2, 3 weeks; 5356 ± 535 µm2 (P = 0.9), 6 weeks; 5857 ± 478 µm2 (P = 0.1). At baseline, there were no differences in fibre myonuclei number between Y and O. RET increased type I fibre myonuclei number from baseline in both Y and O at 3 weeks and 6 weeks with RET (younger: baseline 2.47 ± 0.16, 3 weeks; 3.19 ± 0.16 (P < 0.001), 6 weeks; 3.70 ± 0.29 (P < 0.0001); older: baseline 2.29 ± 0.09, 3 weeks; 3.01 ± 0.09 (P < 0.001), 6 weeks; 3.65 ± 0.18 (P < 0.0001)). Similarly, type II fibre myonuclei number increased from baseline in both Y and O at 3 weeks and 6 weeks (younger: baseline 2.49 ± 0.14, 3 weeks; 3.31 ± 0.21 (P < 0.001), 6 weeks; 3.86 ± 0.29 (P < 0.0001); older: baseline 2.43 ± 0.12, 3 weeks; 3.37 ± 0.12 (P < 0.001), 6 weeks; 3.81 ± 0.15 (P < 0.0001)). DNA synthesis rates %.d-1 exhibited a main effect of training but no age discrimination. Declines in myonuclei addition do not underlie impaired muscle growth capacity in older humans, supporting ribosomal and proteostasis impairments as we have previously reported.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Keyword
- Ageing
- DNA synthesis
- Myonuclei
- Resistance exercise
- Skeletal muscle
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Brook, Matthew S
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Wilkinson, Danie ...
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Tarum, Janelle
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Mitchell, Kyle W
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Lund, Jonathan L
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Phillips, Bethan ...
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Szewczyk, Nathan ...
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Kadi, Fawzi, 197 ...
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Greenhaff, Paul ...
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Smith, Ken
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Atherton, Philip ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Sport and Fitnes ...
- Articles in the publication
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GeroScience
- By the university
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Örebro University