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Magnetic resonance ...
Magnetic resonance and diffusion tensor imaging of the adolescent rabbit growth plate of the knee
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- Kvist, Ola (author)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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- Damberg, Peter (author)
- Karolinska Institute
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- Dou, Zelong (author)
- Karolinska Institute
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- Sanmartin Berglund, Johan, Professor (author)
- Blekinge Institute of Technology,Blekinge Tekniska Högskola,Institutionen för hälsa
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- Flodmark, Carl Erik (author)
- Lund University,Lunds universitet,Preventiv pediatrik,Forskargrupper vid Lunds universitet,Preventive Paediatrics,Lund University Research Groups
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- Nilsson, Ola, 1970- (author)
- Örebro University,Karolinska Institute,Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden
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- Diaz, Sandra (author)
- Karolinska Institute,Lund University,Lunds universitet,Karolinska Institutet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups,Karolinska University Hospital
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(creator_code:org_t)
- 2022-09-15
- 2023
- English.
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In: Magnetic Resonance in Medicine. - : John Wiley & Sons. - 0740-3194 .- 1522-2594. ; 89:1, s. 331-342
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Abstract
Subject headings
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- PURPOSE: To assess the ability of MRI-DTI to evaluate growth plate morphology and activity compared with that of histomorphometry and micro-CT in rabbits.METHODS: The hind limbs of female rabbits aged 16, 20, and 24 wk (n = 4 per age group) were studied using a 9.4T MRI scanner with a multi-gradient echo 3D sequence and DTI in 14 directions (b-value = 984 s/mm2 ). After MRI, the right and left hind limb were processed for histological analysis and micro-CT, respectively. The Wilcoxon signed-rank test was used to evaluate the height and volume of the growth plate. Intraclass correlation and Pearson correlation coefficient were used to evaluate the association between DTI metrics and age.RESULTS: The growth plate height and volume were similar for all modalities at each time point and age. Age was correlated with all tractography and DTI metrics in both the femur and tibia. A correlation was also observed between all the metrics at both sites. Tract number and volume declined with age; however, tract length did not show any changes. The fractional anisotropy color map showed lateral diffusion centrally in the growth plate and perpendicular diffusion in the hypertrophic zone, as verified by histology and micro-CT.CONCLUSION: MRI-DTI may be useful for evaluating the growth plates.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Cartilage
- diffusion-tensor imaging (DTI)
- growth plate
- magnetic resonance imaging (MRI)
- skeletal maturation
- cartilage
- diffusion-tensor imaging (DTI)
- growth plate
- magnetic resonance imaging (MRI)
- skeletal maturation
Publication and Content Type
- ref (subject category)
- art (subject category)
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