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  • Leone, MaricaJanssen Pharmaceutical Companies of Johnson & Johnson, Solna, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden (author)

Genetic and Environmental Contribution to the Co-Occurrence of Endocrine-Metabolic Disorders and Depression : A Nationwide Swedish Study of Siblings

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • HighWire Press,2022
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:oru-101424
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-101424URI
  • https://doi.org/10.1176/appi.ajp.21090954DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151470791URI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • OBJECTIVE: Depression is common in individuals with endocrine-metabolic disorders and vice versa, and a better understanding of the underlying factors contributing to the comorbidity of these disorders is needed. This study investigated the familial coaggregation of depression and endocrine-metabolic disorders and estimated the contribution of genetic and environmental factors to their co-occurrence.METHODS: This population-based cohort study included 2.2 million individuals born in Sweden between 1973 and 1996, with follow-up through 2013. Participants were linked to their biological parents, allowing identification of full siblings, maternal half siblings, and paternal half siblings. Diagnoses of depression and endocrine-metabolic conditions were investigated, with the latter grouped into autoimmune disorders (autoimmune hypothyroidism, Graves' disease, and type 1 diabetes) and non-autoimmune disorders (type 2 diabetes, obesity, and polycystic ovary syndrome). Logistic regression and Cox regression were used to estimate the associations between endocrine-metabolic disorders and depression within the same individual and across siblings. Quantitative genetic modeling was performed to investigate the relative contribution of genetic and environmental influences.RESULTS: Individuals with endocrine-metabolic disorders had a significantly higher risk of depression, with odds ratios ranging from 1.43 (95% CI=1.30, 1.57) for Graves' disease to 3.48 (95% CI=3.25, 3.72) for type 2 diabetes. Increased risks extended to full and half siblings. These correlations were mainly explained by shared genetic influences for non-autoimmune conditions, and by nonshared environmental factors for autoimmune disorders, especially for type 1 diabetes.CONCLUSIONS: These findings provide phenotypic and etiological insights into the co-occurrence of depression and various endocrine-metabolic conditions, which could guide future research aiming at identifying pathophysiological mechanisms and intervention targets.

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  • Kuja-Halkola, RalfKarolinska Institutet (author)
  • Leval, AmyJanssen Pharmaceutical Companies of Johnson & Johnson, Solna, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden (author)
  • Butwicka, AgnieszkaKarolinska Institutet (author)
  • Skov, JakobDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden; Department of Medicine, Karlstad Central Hospital, Karlstad, Sweden (author)
  • Zhang, RuyueDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden (author)
  • Liu, ShengxinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden (author)
  • Larsson, Henrik,1975-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden(Swepub:oru)hiln (author)
  • Bergen, Sarah E.Karolinska Institutet (author)
  • Karolinska InstitutetJanssen Pharmaceutical Companies of Johnson & Johnson, Solna, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden (creator_code:org_t)

Related titles

  • In:American Journal of Psychiatry: HighWire Press179:11, s. 824-8320002-953X1535-7228

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