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  • Tingö, Lina,1984-Linköpings universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden,Nutrition-Gut-Brain Interactions Research Centre,Avdelningen för inflammation och infektion,Medicinska fakulteten,Orebro Univ, Sweden; Orebro Univ, Sweden (author)

Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic Low-Grade Inflammation-A Randomized, Placebo-Controlled Trial

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-09-27
  • MDPI,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-101799
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-101799URI
  • https://doi.org/10.3390/nu14193998DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-189487URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agency:Pfizer Consumer Healthcare
  • Funding Agencies|Pfizer Consumer Healthcare
  • Probiotic and omega-3 supplements have been shown to reduce inflammation, and dual supplementation may have synergistic health effects. We investigated if the novel combination of a multi-strain probiotic (containing B. lactis Bi-07, L. paracasei Lpc-37, L. acidophilus NCFM, and B. lactis Bl-04) alongside omega-3 supplements reduces low-grade inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) in elderly participants in a proof-of-concept, randomized, placebo-controlled, parallel study (NCT04126330). In this case, 76 community-dwelling elderly participants (median: 71.0 years; IQR: 68.0-73.8) underwent an intervention with the dual supplement (n = 37) or placebo (n = 39) for eight weeks. In addition to hs-CRP, cytokine levels and intestinal permeability were also assessed at baseline and after the eight-week intervention. No significant difference was seen for hs-CRP between the dual supplement group and placebo. However, interestingly, supplementation did result in significant increases in the level of the anti-inflammatory marker IL-10. In addition, dual supplementation increased levels of valeric acid, further suggesting the potential of the supplements in reducing inflammation and conferring health benefits. Together, the results suggest that probiotic and omega-3 dual supplementation exerts modest effects on inflammation and may have potential use as a non-pharmacological treatment for low-grade inflammation in the elderly.

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  • Hutchinson, Ashley N.,1984-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre,Orebro Univ, Sweden(Swepub:oru)ayhn (author)
  • Bergh, Cecilia,1972-Örebro universitet,Institutionen för hälsovetenskaper,Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden,Orebro Univ, Sweden(Swepub:oru)cbh (author)
  • Stiefvatter, LenaDepartment of Nutritional Medicine and Prevention, University of Hohenheim, Stuttgart, Germany,Univ Hohenheim, Germany (author)
  • Schweinlin, AnnaDepartment of Nutritional Medicine and Prevention, University of Hohenheim, Stuttgart, Germany,Univ Hohenheim, Germany (author)
  • Jensen, Morten G.GSK Consumer Healthcare ApS, Vallensbæk Strand, Denmark (author)
  • Krüger, KirstenHuman Nutrition & Health, Department of Agrotechnology and Food Sciences, Wageningen University & Research, Wageningen, The Netherland,Wageningen Univ & Res, Netherlands (author)
  • Bischoff, Stephan C.Department of Nutritional Medicine and Prevention, University of Hohenheim, Stuttgart, Germany,Univ Hohenheim, Germany (author)
  • Brummer, Robert Jan,1957-Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre,Orebro Univ, Sweden; Orebro Univ, Sweden(Swepub:oru)rnbr (author)
  • Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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  • In:Nutrients: MDPI14:192072-6643

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