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Effectiveness of ph...
Effectiveness of pharmacogenomic tests including CYP2D6 and CYP2C19 genomic variants for guiding the treatment of depressive disorders : Systematic review and meta-analysis of randomized controlled trials
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- Danilo, Arnone (author)
- United Arab Emirates University, College of Medicine and Health Sciences, Al Ain, United Arab Emirates; Centre for Affective Disorders, Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom
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- Omar, Omar (author)
- University of Birmingham, Birmingham Clinical Trials Unit, Birmingham, United Kingdom
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- Arora, Teresa (author)
- Zayed University, College of Natural & Health Sciences, Abu Dhabi, United Arab Emirates
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- Östlundh, Linda, 1973- (author)
- Örebro universitet,Universitetsbiblioteket
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- Ramaraj, Reshma (author)
- United Arab Emirates University, College of Medicine and Health Sciences, Al Ain, United Arab Emirates
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- Javaid, Syed (author)
- United Arab Emirates University, College of Medicine and Health Sciences, Al Ain, United Arab Emirates
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- Govender, Romona Devi (author)
- Department of Family Medicine, United Arab Emirates University, Al Ain, United Arab Emirates
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- Ali, Bassam R. (author)
- Department of Genetics and Genomics, United Arab Emirates University, Al Ain, United Arab Emirates
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- Patrinos, George P. (author)
- Department of Genetics and Genomics, United Arab Emirates University, Al Ain, United Arab Emirates; Department of Pharmacy, University of Patras School of Health Sciences, Patras, Greece
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- Young Allan, H. (author)
- Centre for Affective Disorders, Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom; South London and Maudsley NHS Foundation Trust, London, United Kingdom
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- Stip, Emmanuel (author)
- United Arab Emirates University, College of Medicine and Health Sciences, Al Ain, United Arab Emirates; University de Montréal, Institute University en Santé Mentale de Montréal, Montreal, Canada
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(creator_code:org_t)
- Pergamon Press, 2023
- 2023
- English.
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In: Neuroscience and Biobehavioral Reviews. - : Pergamon Press. - 0149-7634 .- 1873-7528. ; 144
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Major depressive disorders are prevalent conditions with limited treatment response and remission. Pharmacogenomics tests including CYP2D6 and CYP2C19 genomic variants provide the most reliable actionable approach to guide choice and dosing of antidepressants in major depression to improve outcome. We carried out a meta-analysis and meta-regression analyses of randomised controlled trials evaluating pharmacogenomic tests with CYP2D6 and CYP2C19 polymorphisms in major depression. A systematic review was conducted according to PRISMA and Cochrane guidelines to search several electronic databases. Logarithmically transformed odds ratios (OR) and confidence intervals (CI) for improvement, response and remission were calculated. A random-effects meta-analysis and meta-regression analyses were subsequently carried out. Twelve randomised controlled trials were included. Pharmacogenomic tests in the treatment of depression were more effective than treatment as usual for improvement (OR:1.63, CI: 1.19-2.24), response (OR: 1.46; CI: 1.16-1.85) and remission (OR: 1.85; CI: 1.23-2.76) with no evidence of publication bias. Remission was less favourable in recent studies. The results are promising but cautious use of pharmacogenomics in major depression is advisable. PROSPERO registration ID: CRD42021261143.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- CYP2C19
- CYP2D6
- CYP450
- Pharmacogenomics
- depressive disorders
- major depression
- mood disorders
- pharmacogenetics
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Danilo, Arnone
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Omar, Omar
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Arora, Teresa
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Östlundh, Linda, ...
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Ramaraj, Reshma
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Javaid, Syed
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Govender, Romona ...
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Ali, Bassam R.
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Patrinos, George ...
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Young Allan, H.
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Stip, Emmanuel
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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Örebro University