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SARS-COV2 exposure ...
SARS-COV2 exposure rates and serological response of people living with MS
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- Longinetti, E. (author)
- Karolinska Institutet, Clinical Neuroscience, Stockholm, Sweden
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- Högelin, K. Asplund (author)
- Karolinska Institutet, Clinical Neuroscience, Stockholm, Sweden
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- Kockum, I. (author)
- Karolinska Institutet, Clinical Neuroscience, Stockholm, Sweden
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- Englund, S. (author)
- Karolinska Institutet, Clinical Neuroscience, Stockholm, Sweden
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- Burman, J. (author)
- Uppsala University, Neuroscience, Uppsala, Sweden
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- Fink, K. (author)
- Karolinska Institutet, Clinical Neuroscience, Stockholm, Sweden
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- Fogdell-Hahn, A. (author)
- Karolinska Institutet, Clinical Neuroscience, Stockholm, Sweden
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- Gunnarsson, Martin, 1973- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län
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- Hillert, J. (author)
- Karolinska Institutet, Clinical Neuroscience, Stockholm, Sweden
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- Nilsson, P. (author)
- KTH Royal Institute of Technology, Protein Science, Stockholm, Sweden
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- Langer-Gould, A. (author)
- Southern California Permanente Medical Group, Kaiser Permanente, Clinical and Translational Neuroscience, Los Angeles, United States
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- Lycke, J. (author)
- University of Gothenburg, Clinical Neuroscience, Gothenburg, Sweden
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- Salzer, J. (author)
- Umeå University, Clinical Sciences, Neurosciences, Umeå, Sweden
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- Svenningsson, A. (author)
- Danderyd Hospital, Karolinska Institutet, Clinical Sciences, Stockholm, Sweden
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- Mellergård, J. (author)
- Linköping University, Biomedical and Clinical Sciences, Linköping, Sweden
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- Frisell, T. (author)
- Karolinska Institutet, Medicine Solna, Clinical Epidemiology Division, Stockholm, Sweden
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- Olsson, T. (author)
- Karolinska Institutet, Clinical Neuroscience, Stockholm, Sweden
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- Piehl, F. (author)
- Karolinska Institutet, Clinical Neuroscience, Stockholm, Sweden
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(creator_code:org_t)
- Sage Publications, 2022
- 2022
- English.
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In: Multiple Sclerosis Journal. - : Sage Publications. - 1352-4585 .- 1477-0970. ; 28:Suppl. 3, s. 515-516
- Related links:
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https://urn.kb.se/re...
Abstract
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- Introduction: Some multiple sclerosis (MS) disease-modifying therapies (DMTs) are associated with blunted humoral vaccination responses, but relevance for SARS-CoV-2 infection is unclear.Objectives: To determine SARS-CoV-2 exposure rates and formation of antibody memory among participants of the COMparison Between All immunoTherapies for MS (COMBAT-MS; NCT03193866) and the Immunomodulation and MS Epidemiology (IMSE) studies.Aim: To determine SARS-CoV2 serological response of people living with MS (pwMS).Methods: Using a multiplex bead-based assay we determined SARS-CoV-2 spike and nucleocapsid antibody levels in 3,723 pwMS in paired serum samples (n=7,157) donated prior (Results: Specificity and sensitivity of the assay for SARS-CoV-2 was 100% and 99.7%, respectively. The proportion of positive samples for SARS-CoV-2 differed moderately across DMTs with the highest values among cladribine-treated (7.4%) and the lowest number among rituximab-treated pwMS (3.9%). Similarly, the proportion of positive cases not reported in the Swedish MS registry varied from 100% for cladribine to 33.3% among untreated pwMS. Comparing levels of antibodies titers showed that levels were lower among those treated with rituximab or fingolimod vs interferon treated pwMS. Point estimates indicated a similar trend comparing rituximab or fingolimod vs untreated pwMS.Conclusions: Overall rates of SARS-CoV-2 antibody positivity after the first COVID-19 wave differed only moderately across DMTs, while antibody levels were lower with rituximab or fingolimod compared to interferon-treated pwMS. This indicates quantitative rather than qualitative differences in the humoral response to infection.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- vet (subject category)
- art (subject category)
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- By the author/editor
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Longinetti, E.
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Högelin, K. Aspl ...
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Kockum, I.
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Englund, S.
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Burman, J.
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Fink, K.
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show more...
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Fogdell-Hahn, A.
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Gunnarsson, Mart ...
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Hillert, J.
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Nilsson, P.
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Langer-Gould, A.
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Lycke, J.
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Salzer, J.
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Svenningsson, A.
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Mellergård, J.
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Frisell, T.
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Olsson, T.
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Piehl, F.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Multiple Scleros ...
- By the university
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Örebro University