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  • Stuart, Kelsey V.NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK (author)

The association of alcohol consumption with glaucoma and related traits : findings from the UK Biobank

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Elsevier,2023
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:oru-102644
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-102644URI
  • https://doi.org/10.1016/j.ogla.2022.11.008DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies:UCL Overseas Research Scholarship, Fight for Sight (London) 1956AThe Desmond FoundationMoorfields EyeCharity Springboard AwardGeneral Sir John Monash ScholarshipThe Glaucoma FoundationResearch to Prevent BlindnessNational Institutes of Health EY015473 EY032559 EY032559 EY027129 EY014104 EY022305 EY020928 EY031820) AerpioARVO FoundationDavid Epstein AwardAlconFight for Sight (London) 1956AUK Research and Innovation Future Leaders Fellowship MR/T040912/1Moorfields Eye Charity Career Development FellowshipLister Institute of Preventative Medicine FellowshipFoundation Trust and University College LondonInstitute of Ophthalmology for a Biomedical Research Centre
  • PURPOSE: To examine the associations of alcohol consumption with glaucoma and related traits; to assess whether a genetic predisposition to glaucoma modified these associations; and to perform Mendelian randomization (MR) experiments to probe causal effects.DESIGN: Cross-sectional observational and gene-environment interaction analyses in the UK Biobank. Two-sample MR experiments using summary statistics from large genetic consortia.PARTICIPANTS: UK Biobank participants with data on intraocular pressure (IOP) (n=109 097), OCT derived macular inner retinal layer thickness measures (n=46 236) and glaucoma status (n=173 407).METHODS: Participants were categorized according to self-reported drinking behaviors. Quantitative estimates of alcohol intake were derived from touchscreen questionnaires and food composition tables. We performed a two-step analysis, first comparing categories of alcohol consumption (never, infrequent, regular, and former drinkers), before assessing for a dose-response effect in regular drinkers only. Multivariable linear, logistic and restricted cubic spline (RCS) regression, adjusted for key sociodemographic, medical, anthropometric and lifestyle factors, were used to examine associations. We assessed whether any association was modified by a multi-trait glaucoma polygenic risk score. The inverse-variance weighted method was used for the main MR analyses.MAIN OUTCOME MEASURES: IOP, macular retinal nerve fiber layer (mRNFL) thickness, macular ganglion cell-inner plexiform layer (mGCIPL) thickness, and prevalent glaucoma. RESULTS: Compared to infrequent drinkers, regular drinkers had higher IOP (+0.17mmHg; P<0.001) and thinner mGCIPL (-0.17μm; P=0.049); while former drinkers had a higher prevalence of glaucoma (OR 1.53; P=0.002). In regular drinkers, alcohol intake was adversely associated with all outcomes in a dose-dependent manner (all P<0.001). RCS regression analyses suggested non-linear associations, with apparent threshold effects at approximately 50g (∼6 UK or 4 US alcoholic units)/week, for mRNFL and mGCIPL thickness. Significantly stronger alcohol-IOP associations were observed in participants at higher genetic susceptibility to glaucoma (Pinteraction<0.001). MR analyses provided evidence for a causal association with mGCIPL thickness.CONCLUSIONS: Alcohol intake was consistently and adversely associated with glaucoma and related traits, and at levels below current UK (<112g/week) and US (women: <98g/week; men: <196g/week) guidelines. While we cannot infer causality definitively, these results will be of interest to people with, or at risk of, glaucoma and their advising physicians.

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  • Luben, Robert N.NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK (author)
  • Warwick, Alasdair N.NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK; UCL Institute of Cardiovascular Science, University College London, London, UK (author)
  • Madjedi, Kian M.NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK; Department of Ophthalmology, University of Calgary, Calgary, AB, Canada (author)
  • Patel, Praveen J.NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK (author)
  • Biradar, Mahantesh I.NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK (author)
  • Sun, ZihanNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK (author)
  • Chia, Mark A.NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK (author)
  • Pasquale, Louis R.Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, USA (author)
  • Wiggs, Janey L.Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA (author)
  • Kang, Jae H.Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA (author)
  • Kim, JihyeDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA (author)
  • Aschard, HuguesDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA; Institut Pasteur, Université Paris Cité, Department of Computational Biology, F-75015 Paris, France (author)
  • Tran, Jessica H.Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, USA (author)
  • Lentjes, Marleen A. H.,1974-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)mals (author)
  • Foster, Paul J.NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK (author)
  • Khawaja, Anthony P.NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK (author)
  • The International Glaucoma Genetics Consortium, - (contributor)
  • NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UKNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK (creator_code:org_t)

Related titles

  • In:Ophthalmology Glaucoma: Elsevier6:4, s. 366-3792589-42342589-4196

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