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  • Englund, SimonKarolinska Institute,Karolinska Inst, Sweden (author)

Predictors of patient-reported fatigue symptom severity in a nationwide multiple sclerosis cohort

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Elsevier,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-103138
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-103138URI
  • https://doi.org/10.1016/j.msard.2022.104481DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-211816URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151698512URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-496704URI
  • https://lup.lub.lu.se/record/83467911-3608-4dbf-8e62-081b5eb04f39URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-191749URI
  • https://gup.ub.gu.se/publication/324253URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agency:NEURO Sweden
  • Funding Agencies|Patient-Centered Outcomes Research Institute (PCORI) Award [MS-1511-33196]; Swedish Research Council [2020-02700, TF 2016-01355]; Swedish Research Council for Health, Working Life, and Welfare [2020-0115]; NEURO Sweden
  • BACKGROUND: Fatigue is a debilitating symptom of multiple sclerosis (MS), but its relation to sociodemographic and disease-related characteristics has not been investigated in larger studies. The objectives of this study were to evaluate predictors of self-reported fatigue in a Swedish nationwide register-based MS cohort.METHODS: Using a repeated cross-sectional design, we included 2,165 persons with relapsing- remitting and secondary progressive MS with one or multiple Fatigue Scale for Motor and Cognitive Functions (FSMC) scores, which was modelled using multivariable linear regressions for multiple predictors.RESULTS: Only associations to expanded disability status scale (EDSS) and Symbol Digit Modalities Test (SDMT) were considered clinically meaningful among MS-associated characteristics in our main model; compared to mild disability (EDSS 0-2.5), those with severe disability (EDSS ≥6) scored 17.6 (95% CI 13.1-22.2) FSMC points higher, while the difference was 10.7 (95% CI 8.0-13.4) points for the highest and lowest quartiles of SDMT. Differences between highest and lowest quartiles of health-related quality of life (HRQoL) instruments were even greater and considered clinically meaningful; EuroQoL Visual Analogue Scale (EQ-VAS) 31.9 (95% CI 29.9-33.8), Multiple Sclerosis Impact Scale (MSIS-29) psychological component 35.6 (95% CI 33.8-37.4) and MSIS-29 physical component 45.5 (95% CI 43.7-47.4).CONCLUSION: Higher self-reported fatigue is associated with higher disability level and worse cognitive processing speed, while associations to other MS-associated characteristics including MS type, line of disease modifying therapy (DMT), MS duration, relapse and new cerebral lesions are weak. Furthermore, we found a strong correlation between high fatigue rating and lower ratings on health-related quality of life instruments.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kierkegaard, MarieKarolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden. (author)
  • Burman, Joachim,1974-Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Neurosci, Uppsala, Sweden.(Swepub:uu)joabu293 (author)
  • Fink, KatharinaKarolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden. (author)
  • Fogdell-Hahn, AnnaKarolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden. (author)
  • Gunnarsson, Martin,1973-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Neurology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Fac Med & Hlth, Dept Neurol, Orebro, Sweden.(Swepub:oru)mign (author)
  • Hillert, JanKarolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden. (author)
  • Langer-Gould, AnnetteClinical and Translational Neuroscience, Southern California Permanente Medical Group, Kaiser Permanente, Pasadena, United States,Kaiser Permanente, Southern Calif Permanente Med Grp, Clin & Translat Neurosci, Pasadena, CA USA. (author)
  • Lycke, Jan,1956Gothenburg University,Göteborgs universitet,University of Gothenburg,Univ Gothenburg, Sweden,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xlycja (author)
  • Nilsson, PetraLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden(Swepub:lu)neur-pn8 (author)
  • Salzer, JonatanUmeå University,Umeå universitet,Neurovetenskaper,Umea Univ, Dept Pharmacol & Clin Neurosci, Umea, Sweden.(Swepub:umu)jonser01 (author)
  • Svenningsson, AndersKarolinska Institutet,Danderyd Hosp Stockholm, Clin Sci, Stockholm, Sweden.,Danderyd Hospital (author)
  • Mellergård, JohanLinköpings universitet,Linköping University,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping(Swepub:liu)johme15 (author)
  • Olsson, TomasKarolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden. (author)
  • Longinetti, ElisaKarolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden. (author)
  • Frisell, ThomasKarolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden. (author)
  • Piehl, FredrikKarolinska Institute,Karolinska Inst, Sweden (author)
  • Karolinska InstituteKarolinska Inst, Sweden (creator_code:org_t)

Related titles

  • In:Multiple Sclerosis and Related Disorders: Elsevier702211-03482211-0356

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