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Opioid Use After Ga...
Opioid Use After Gastric Bypass, Sleeve Gastrectomy or Intensive Lifestyle Intervention
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- Wallén, Stefan, 1978- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Pharmacology and Therapeutic Department, Region Örebro County, University Hospital of Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Surg, Örebro, Sweden.;Univ Hosp Örebro, Pharmacol & Therapeut Dept, Reg Örebro Cty, Örebro, Sweden.
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- Bruze, Gustaf (author)
- Karolinska Institutet
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- Ottosson, Johan, 1957- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery,Örebro Univ, Fac Med & Hlth, Dept Surg, Örebro, Sweden.
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- Marcus, Claude (author)
- Karolinska Institutet
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- Sundström, Johan, Professor, 1971- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala Univ, Sweden
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- Szabo, Eva, PhD, 1973- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery,Örebro Univ, Fac Med & Hlth, Dept Surg, Örebro, Sweden.
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- Olbers, Torsten (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken ViN,Wallenberg Centre for Molecular Medicine
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- Ekbäck, Maria Palmetun, 1961- (author)
- Pharmacology and Therapeutic Department, Region Örebro County, University Hospital of Örebro, Sweden,Univ Hosp Örebro, Pharmacol & Therapeut Dept, Reg Örebro Cty, Örebro, Sweden.
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- Näslund, Ingmar (author)
- Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Surg, Örebro, Sweden.
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- Neovius, Martin (author)
- Karolinska Institutet
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2023
- 2023
- English.
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In: Annals of Surgery. - : Lippincott Williams & Wilkins. - 0003-4932 .- 1528-1140. ; 277:3, s. e552-e560
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https://doi.org/10.1...
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Abstract
Subject headings
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- OBJECTIVE: To compare opioid use in patients with obesity treated with bariatric surgery versus adults with obesity who underwent intensive lifestyle modification. SUMMARY OFBACKGROUND DATA: Previous studies of opioid use after bariatric surgery have been limited by small sample sizes, short follow-up, and lack of control groups.METHODS: Nationwide matched cohort study including individuals from the Scandinavian Obesity Surgery Registry and the Itrim health database with individuals undergoing structured intensive lifestyle modification, between August 1, 2007 and September 30, 2015. Participants were matched on Body Mass Index, age, sex, education, previous opioid use, diabetes, cardiovascular disease, and psychiatric status (n = 30,359:21,356). Dispensed opioids were retrieved from the Swedish Prescribed Drug Register from 2 years before to up to 8 years after intervention.RESULTS: During the 2-year period before treatment, prevalence of individuals receiving ≥1 opioid prescription was identical in the surgery and lifestyle group. At 3 years, the prevalence of opioid prescriptions was 14.7% versus 8.9% in the surgery and lifestyle groups (mean difference 5.9%, 95% confidence interval 5.3-6.4) and at 8 years 16.9% versus 9.0% (7.9%, 6.8-9.0). The difference in mean daily dose also increased over time and was 3.55 mg in the surgery group versus 1.17 mg in the lifestyle group at 8 years (mean difference [adjusted for baseline dose] 2.30 mg, 95% confidence interval 1.61-2.98).CONCLUSIONS: Bariatric surgery was associated with a higher proportion of opioid users and larger total opioid dose, compared to actively treated obese individuals. These trends were especially evident in patients who received additional surgery during follow-up.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- bariatric surgery
- gastric bypass surgery
- obesity
- opioids
- sleeve gastrectomy
- weight loss
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wallén, Stefan, ...
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Bruze, Gustaf
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Ottosson, Johan, ...
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Marcus, Claude
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Sundström, Johan ...
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Szabo, Eva, PhD, ...
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show more...
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Olbers, Torsten
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Ekbäck, Maria Pa ...
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Näslund, Ingmar
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Neovius, Martin
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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Annals of Surger ...
- By the university
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Örebro University
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Uppsala University
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Linköping University
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Karolinska Institutet