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  • Wallén, Stefan,1978-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Pharmacology and Therapeutic Department, Region Örebro County, University Hospital of Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Surg, Örebro, Sweden.;Univ Hosp Örebro, Pharmacol & Therapeut Dept, Reg Örebro Cty, Örebro, Sweden. (author)

Opioid Use After Gastric Bypass, Sleeve Gastrectomy or Intensive Lifestyle Intervention

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Lippincott Williams & Wilkins,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-103633
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-103633URI
  • https://doi.org/10.1097/SLA.0000000000005192DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-498875URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-192302URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:152000738URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies:Funding Grants Office at Region Örebro County United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA
  • Funding Agencies|Funding Grants Office at Region Orebro County; US National Institutes of Health; Swedish Research Council; Swedish Research Council for Health, Working Life and Welfare
  • OBJECTIVE: To compare opioid use in patients with obesity treated with bariatric surgery versus adults with obesity who underwent intensive lifestyle modification. SUMMARY OFBACKGROUND DATA: Previous studies of opioid use after bariatric surgery have been limited by small sample sizes, short follow-up, and lack of control groups.METHODS: Nationwide matched cohort study including individuals from the Scandinavian Obesity Surgery Registry and the Itrim health database with individuals undergoing structured intensive lifestyle modification, between August 1, 2007 and September 30, 2015. Participants were matched on Body Mass Index, age, sex, education, previous opioid use, diabetes, cardiovascular disease, and psychiatric status (n = 30,359:21,356). Dispensed opioids were retrieved from the Swedish Prescribed Drug Register from 2 years before to up to 8 years after intervention.RESULTS: During the 2-year period before treatment, prevalence of individuals receiving ≥1 opioid prescription was identical in the surgery and lifestyle group. At 3 years, the prevalence of opioid prescriptions was 14.7% versus 8.9% in the surgery and lifestyle groups (mean difference 5.9%, 95% confidence interval 5.3-6.4) and at 8 years 16.9% versus 9.0% (7.9%, 6.8-9.0). The difference in mean daily dose also increased over time and was 3.55 mg in the surgery group versus 1.17 mg in the lifestyle group at 8 years (mean difference [adjusted for baseline dose] 2.30 mg, 95% confidence interval 1.61-2.98).CONCLUSIONS: Bariatric surgery was associated with a higher proportion of opioid users and larger total opioid dose, compared to actively treated obese individuals. These trends were especially evident in patients who received additional surgery during follow-up.

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  • Bruze, GustafKarolinska Institutet (author)
  • Ottosson, Johan,1957-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery,Örebro Univ, Fac Med & Hlth, Dept Surg, Örebro, Sweden.(Swepub:oru)jhon (author)
  • Marcus, ClaudeKarolinska Institutet (author)
  • Sundström, Johan,Professor,1971-Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala Univ, Sweden(Swepub:uu)johasund (author)
  • Szabo, Eva,PhD,1973-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery,Örebro Univ, Fac Med & Hlth, Dept Surg, Örebro, Sweden.(Swepub:oru)eso (author)
  • Olbers, TorstenLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken ViN,Wallenberg Centre for Molecular Medicine(Swepub:liu)torol42 (author)
  • Ekbäck, Maria Palmetun,1961-Pharmacology and Therapeutic Department, Region Örebro County, University Hospital of Örebro, Sweden,Univ Hosp Örebro, Pharmacol & Therapeut Dept, Reg Örebro Cty, Örebro, Sweden.(Swepub:oru)mpk (author)
  • Näslund, IngmarDepartment of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Surg, Örebro, Sweden. (author)
  • Neovius, MartinKarolinska Institutet (author)
  • Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

  • In:Annals of Surgery: Lippincott Williams & Wilkins277:3, s. e552-e5600003-49321528-1140

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