Systemic inflammation measured by erythrocyte sedimentation rate and cognitive function among young men in Sweden: A within-sibling analysis

Xu, YinClinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden; Department of Sociology and Psychology, School of Public Administration, Sichuan University, Chengdu, China (författare)

Systemic inflammation measured by erythrocyte sedimentation rate and cognitive function among young men in Sweden : A within-sibling analysis

Funding agency:UK Research & Innovation (UKRI)Economic & Social Research Council (ESRC) ES/R008930/1
This study assesses the extent to which the association between erythrocyte sedimentation rate, a marker of inflammation, and cognitive function is explained by shared familial factors using within-sibling analyses. Men who were born in Sweden between 1950 and 1965 and recorded in the Swedish Military Conscription Register between 1969 and 1983 were included (N = 632,396). Erythrocyte sedimentation rate and cognitive function were measured at the conscription assessment (median age = 18.3 years, with a range from 15.5 to 28.5 years). Conventional linear regression and multilevel linear regression with a hybrid modeling approach were used, with the latter to obtain within-effect estimation in which unmeasured familial confounding shared by siblings was controlled for. We found that the association between erythrocyte sedimentation rate and cognitive function at conscription assessment was partly accounted for by, but remained independent of, shared familial factors.

Hiyoshi, Ayako,1972-Stockholms universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden; Department of Public Health Sciences, Stockholm University, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, UK,Institutionen för folkhälsovetenskap(Swepub:su)ayhi0031 (författare)
Fall, Katja,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden; Department of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)kafl (författare)
Montgomery, Scott,1961-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden; Department of Epidemiology and Public Health, University College London, London, UK; Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)smy (författare)
Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden; Department of Sociology and Psychology, School of Public Administration, Sichuan University, Chengdu, ChinaInstitutionen för medicinska vetenskaper (creator_code:org_t)

Av författaren/redakt...: Xu, Yin; Hiyoshi, Ayako, ...; Fall, Katja, 197 ...; Montgomery, Scot ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

Av lärosätet: Örebro universitet; Stockholms universitet; Karolinska Institutet

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