SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:oru-105191"
 

Search: onr:"swepub:oai:DiVA.org:oru-105191" > Associations betwee...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Dunder, LindaUppsala University,Uppsala universitet,Arbets- och miljömedicin (author)

Associations between per- and polyfluoroalkyl substances (PFAS) and diabetes in two population-based cohort studies from Sweden

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023-03-24
  • Nature Publishing Group,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-105191
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-105191URI
  • https://doi.org/10.1038/s41370-023-00529-xDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-517943URI
  • https://lup.lub.lu.se/record/e25fa66e-7fd1-4545-809b-e19a8dc0ca4fURI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agency:Uppsala University Hospital (ALF)
  • BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) have been suggested to contribute to the development of metabolic diseases such as obesity, diabetes and non-alcoholic fatty liver disease (NAFLD). However, evidence from epidemiological studies remain divergent. The aim of the present study was to evaluate associations between PFAS exposure and prevalent diabetes in a cross-sectional analysis and fasting glucose in a longitudinal analysis.METHODS: In 2373 subjects aged 45-75 years from the EpiHealth study, three PFAS; perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) were analyzed in plasma together with information on prevalent diabetes. Participants in the PIVUS study (n = 1016 at baseline, all aged 70 years) were followed over 10 years regarding changes in plasma levels of six PFAS; PFHxS, PFOA, PFOS, perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA), and changes in plasma levels of fasting glucose.RESULTS: In the EpiHealth study, no overall associations could be observed between the levels of PFOA, PFOS or PFHxS and prevalent diabetes. However, there was a significant sex-interaction for PFOA (p = 0.02), and an inverse association could be seen between PFOA (on a SD-scale) and prevalent diabetes in women only (OR: 0.71, 95% CI: 0.52, 0.96, p-value: 0.02). This association showed a non-monotonic dose-response curve. In the PIVUS study, inverse relationships could be observed between the changes in levels (ln-transformed) of PFOA and PFUnDA vs the change in fasting glucose levels (ln-transformed) over 10 years (p = 0.04 and p = 0.02, respectively). As in EpiHealth, these inverse associations were significant only in women (PFOA: β: -0.03, p = 0.02, PFUnDA: β: -0.03, p = 0.03).IMPACT: Exposure to per- and polyfluoroalkyl substances (PFAS) has been linked to unfavorable human health, including metabolic disorders such as obesity, diabetes and non-alcoholic fatty liver disease. However, results from in vivo, in vitro and epidemiological studies are incoherent. The aim of the present study was therefore to investigate associations between PFAS and diabetes in a cross-sectional study and glucose levels in a longitudinal study. Results show inverse associations in women only. Results also display non-monotonic dose response curves (i.e., that only low levels of PFOA are related to higher probability of prevalent diabetes). This suggests that sex differences and complex molecular mechanisms may underlie the observed findings. A better understanding of the factors and molecular mechanisms contributing to such differences is recognized as an important direction for future research.CONCLUSIONS: PFOA was found to be inversely related to both prevalent diabetes and changes in plasma glucose levels among women only. Thus, our findings suggest there are sex differences in the inverse relationship of PFOA and type 2 diabetes and glucose levels.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Salihovic, Samira,Associate Senior Lecturer,1985-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Sch Med Sci, Örebro, Sweden.(Swepub:oru)sasc (author)
  • Elmståhl, SölveLund University,Lunds universitet,Geriatrik,Forskargrupper vid Lunds universitet,Geriatrics,Lund University Research Groups(Swepub:lu)smi-sel (author)
  • Lind, P. Monica,1957-Uppsala University,Uppsala universitet,Arbets- och miljömedicin(Swepub:uu)monilind (author)
  • Lind, LarsUppsala University,Uppsala universitet,Klinisk epidemiologi(Swepub:uu)larslind (author)
  • Uppsala universitetArbets- och miljömedicin (creator_code:org_t)

Related titles

  • In:Journal of Exposure Science and Environmental Epidemiology: Nature Publishing Group33:5, s. 748-7561559-06311559-064X

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Find more in SwePub

By the author/editor
Dunder, Linda
Salihovic, Samir ...
Elmståhl, Sölve
Lind, P. Monica, ...
Lind, Lars
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Endocrinology an ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
and Occupational Hea ...
Articles in the publication
Journal of Expos ...
By the university
Örebro University
Uppsala University
Lund University

Search outside SwePub

Wikipedia about the author:
Linda_Dunder
Dunder, Linda
en

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view