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Inflammatory Bowel ...
Inflammatory Bowel Disease and Risk of Colorectal Polyps : A nationwide population-based cohort study from Sweden
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- Axelrad, Jordan (author)
- Inflammatory Bowel Disease Center at NYU Langone Health, Division of Gastroenterology, Department of Medicine, NYU School of Medicine, New York, New York, USA
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- Olén, Ola (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Stockholm South Gen Hosp, Sweden; Karolinska Inst, Sweden
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- Söderling, Jonas (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Roelstraete, Bjorn (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
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- Khalili, Hamed (author)
- Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA,Massachusetts Gen Hosp, MA USA
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- Song, Mingyang (author)
- Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
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- Faye, Adam (author)
- Inflammatory Bowel Disease Center at NYU Langone Health, Division of Gastroenterology, Department of Medicine, NYU School of Medicine, New York, New York, USA
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- Eberhardson, Michael (author)
- Linköpings universitet,Karolinska Institutet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken,Karolinska Inst, Sweden
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- Halfvarson, Jonas, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden
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- Ludvigsson, Jonas F., 1969- (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Orebro Univ Hosp, Sweden; Columbia Univ, NY USA
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(creator_code:org_t)
- 2023-03-30
- 2023
- English.
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In: Journal of Crohn's & Colitis. - : Oxford University Press. - 1873-9946 .- 1876-4479. ; 17:9, s. 1395-1409
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Inflammatory bowel disease (IBD) has been linked to an increased risk of colorectal neoplasia. However, the types and risks of specific polyp types in IBD are less clear.METHODS: We identified 41,880 individuals with IBD [Crohn's disease (CD: n=12,850); Ulcerative colitis (UC): n=29,030)] from Sweden matched with 41,880 reference individuals. Using Cox regression, we calculated adjusted hazard ratios (aHRs) for neoplastic colorectal polyps (Tubular, Serrated/Sessile, Advanced and Villous) defined by histopathology codes.RESULTS: During follow-up, 1648 (3.9%) IBD patients and 1143 (2.7%) reference individuals had an incident neoplastic colorectal polyp, corresponding to an incidence rate of 46.1 and 34.2 per 10,000 person-years, respectively. This correlated to an aHR of 1.23 (95% CI 1.12-1.35) with the highest HRs seen for sessile serrated polyps (8.50, 95% CI 1.10-65.90) and traditional serrated adenomas (1.72, 95% CI 1.02-2.91). aHRs for colorectal polyps were particularly elevated in those diagnosed with IBD at a young age and after 10 years after diagnosis. Both absolute and relative risks of colorectal polyps were higher in UC than in CD (aHRs 1.31 vs. 1.06, respectively), with a 20-year cumulative risk differences of 4.4% in UC and 1.5% in CD, corresponding to one extra polyp in 23 patients with UC and one in 67 CD patients during the first 20 years after IBD diagnosis.CONCLUSIONS: In this nationwide population-based study, there was an increased risk of neoplastic colorectal polyps in IBD patients. Colonoscopic surveillance in IBD appears important, especially in UC and after 10 years of disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Crohn’s disease
- cancer
- dysplasia
- polyp
- ulcerative colitis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Axelrad, Jordan
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Olén, Ola
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Söderling, Jonas
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Roelstraete, Bjo ...
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Khalili, Hamed
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Song, Mingyang
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Faye, Adam
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Eberhardson, Mic ...
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Halfvarson, Jona ...
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Ludvigsson, Jona ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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Journal of Crohn ...
- By the university
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Örebro University
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Karolinska Institutet
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Linköping University