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Immobility-associat...
Immobility-associated thromboprotection is conserved across mammalian species from bear to human
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- Thienel, Manuela (author)
- Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
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- Müller-Reif, Johannes B. (author)
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany; Omicera Diagnostics, 82152 Martinsried, Germany
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- Zhang, Zhe (author)
- Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany
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- Ehreiser, Vincent (author)
- Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
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- Huth, Judith (author)
- Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
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- Shchurovska, Khrystyna (author)
- Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
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- Kilani, Badr (author)
- Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
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- Schweizer, Lisa (author)
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
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- Geyer, Philipp E. (author)
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany; Omicera Diagnostics, 82152 Martinsried, Germany
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- Zwiebel, Maximilian (author)
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
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- Novotny, Julia (author)
- Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany
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- Lüsebrink, Enzo (author)
- Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany
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- Little, Gemma (author)
- Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, Health and Life Sciences Building, University of Reading, RG6 6UR, UK
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- Orban, Martin (author)
- Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany
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- Nicolai, Leo (author)
- Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
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- El Nemr, Shaza (author)
- Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
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- Titova, Anna (author)
- Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
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- Spannagl, Michael (author)
- Anesthesiology and Transfusion Medicine, Cell Therapeutics and Hemostaseology, Ludwig-Maximilians-University Munich, 80336 Munich, Germany
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- Kindberg, Jonas (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för vilt, fisk och miljö,Department of Wildlife, Fish and Environmental Studies,Norwegian Institute Nature Research
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- Evans, Alina L. (author)
- Department of Forestry and Wildlife Management, Faculty of Applied Ecology and Agricultural Sciences, Inland Norway University of Applied Sciences, 2480 Koppang, Norway
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- Mach, Orpheus (author)
- Zentrum für Rückenmarkverletzte mit Neuro-Urologie, BG Unfallklinik Murnau, 82418 Murnau am Staffelsee, Germany
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- Vogel, Matthias (author)
- Zentrum für Rückenmarkverletzte mit Neuro-Urologie, BG Unfallklinik Murnau, 82418 Murnau am Staffelsee, Germany
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- Tiedt, Steffen (author)
- Neurologische Klinik und Poliklinik, Klinikum der Universität München, Ludwig-Maximilians- University Munich, 81377 Munich, Germany
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- Ormanns, Steffen (author)
- Pathologisches Institut, Klinikum der Universität München, Ludwig-Maximilians- University Munich, 81377 Munich, Germany
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- Kessler, Barbara (author)
- Gene Center, Ludwig-Maximilians-University Munich, 81377 Munich, Germany
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- Dueck, Anne (author)
- DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany; Institute of Pharmacology and Toxicology, Technical University of Munich, 80802 Munich, Germany
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- Friebe, Andrea (author)
- Norwegian Institute for Nature Research, 7034 Trondheim, Norway; Scandinavian Brown Bear Research Project, Tackåsen 2, SE-79498 Orsa, Sweden
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- Jørgensen, Peter Godsk (author)
- Herlev and Gentofte University Hospital, Borgmester Ib Juuls Vej 1, DK-2730, Herlev, Copenhagen, Denmark
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- Majzoub-Altweck, Monir (author)
- Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany
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- Blutke, Andreas (author)
- Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany
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- Polzin, Amin (author)
- Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich Heine University Medical Center Dusseldorf, 40225 Dusseldorf, Germany
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- Stark, Konstantin (author)
- Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
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- Kääb, Stefan (author)
- Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
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- Maier, Doris (author)
- Zentrum für Rückenmarkverletzte mit Neuro-Urologie, BG Unfallklinik Murnau, 82418 Murnau am Staffelsee, Germany
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- Gibbins, Jonathan M. (author)
- Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, Health and Life Sciences Building, University of Reading, RG6 6UR, UK
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- Limper, Ulrich (author)
- Institute of Aerospace Medicine, German Aerospace Center (DLR), 51147 Cologne, Germany; Department of Anesthesiology and Intensive Care Medicine, Merheim Medical Center, Hospitals of Cologne, University of Witten/Herdecke, 51109 Cologne, Germany
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- Fröbert, Ole, 1964- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Faculty of Health, Department of Cardiology, Örebro University, 701 85 Örebro, Sweden; Department of Clinical Medicine, Faculty of Health, Aarhus University, 8000 Aarhus, Denmark; Department of Clinical Pharmacology, Aarhus University Hospital, 8000 Aarhus, Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, 8000 Aarhus, Denmark
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- Mann, Matthias (author)
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
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- Massberg, Steffen (author)
- Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
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- Petzold, Tobias (author)
- Department of Cardiology, University Hospital, LMU Munich, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany
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(creator_code:org_t)
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- American Association for the Advancement of Science (AAAS), 2023
- 2023
- English.
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 380:6641, s. 178-187
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://res.slu.se/i...
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Abstract
Subject headings
Close
- Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a major cause of morbidity and mortality. Short-term immobility-related conditions are a major risk factor for the development of VTE. Paradoxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury (SCI) patients are protected from VTE. We aimed to identify mechanisms of immobility-associated VTE protection in a cross-species approach. Mass spectrometry-based proteomics revealed an antithrombotic signature in platelets of hibernating brown bears with heat shock protein 47 (HSP47) as the most substantially reduced protein. HSP47 down-regulation or ablation attenuated immune cell activation and neutrophil extracellular trap formation, contributing to thromboprotection in bears, SCI patients, and mice. This cross-species conserved platelet signature may give rise to antithrombotic therapeutics and prognostic markers beyond immobility-associated VTE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- NATURVETENSKAP -- Biologi -- Zoologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Zoology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Science
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To the university's database
- By the author/editor
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Thienel, Manuela
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Müller-Reif, Joh ...
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Zhang, Zhe
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Ehreiser, Vincen ...
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Huth, Judith
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Shchurovska, Khr ...
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show more...
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Kilani, Badr
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Schweizer, Lisa
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Geyer, Philipp E ...
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Zwiebel, Maximil ...
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Novotny, Julia
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Lüsebrink, Enzo
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Little, Gemma
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Orban, Martin
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Nicolai, Leo
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El Nemr, Shaza
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Titova, Anna
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Spannagl, Michae ...
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Kindberg, Jonas
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Evans, Alina L.
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Mach, Orpheus
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Vogel, Matthias
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Tiedt, Steffen
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Ormanns, Steffen
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Kessler, Barbara
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Dueck, Anne
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Friebe, Andrea
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Jørgensen, Peter ...
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Majzoub-Altweck, ...
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Blutke, Andreas
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Polzin, Amin
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Stark, Konstanti ...
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Kääb, Stefan
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Maier, Doris
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Gibbins, Jonatha ...
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Limper, Ulrich
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Fröbert, Ole, 19 ...
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Mann, Matthias
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Massberg, Steffe ...
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Petzold, Tobias
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Zoology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Science
- By the university
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Örebro University
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Swedish University of Agricultural Sciences