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Antimicrobial susce...
Antimicrobial susceptibility surveillance and antimicrobial resistance in Neisseria gonorrhoeae in Africa from 2001 to 2020 : A mini-review
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- Kakooza, Francis (author)
- Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda; Department of Immunology and Molecular Biology, Makerere University College of Health Sciences, Kampala, Uganda
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- Kiggundu, Reuben (author)
- USAID Medicines, Technologies, and Pharmaceutical Services (MTaPS) Program, Management Sciences for Health, Kampala, Uganda
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- Mboowa, Gerald (author)
- Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda; Department of Immunology and Molecular Biology, Makerere University College of Health Sciences, Kampala, Uganda
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- Kateete, Patrick David (author)
- Department of Immunology and Molecular Biology, Makerere University College of Health Sciences, Kampala, Uganda
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- Nsangi, Olga Tendo (author)
- Department of Immunology and Molecular Biology, Makerere University College of Health Sciences, Kampala, Uganda
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- Kabahita, Jupiter Marina (author)
- Department of Immunology and Molecular Biology, Makerere University College of Health Sciences, Kampala, Uganda
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- Ssentalo Bagaya, Bernard (author)
- Department of Immunology and Molecular Biology, Makerere University College of Health Sciences, Kampala, Uganda
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- Golparian, Daniel, 1984- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Örebro University, Örebro, Sweden
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- Unemo, Magnus, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Örebro University, Örebro, Sweden; Institute for Global Health, University College London (UCL), London, United Kingdom
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(creator_code:org_t)
- Frontiers Media S.A. 2023
- 2023
- English.
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In: Frontiers in Microbiology. - : Frontiers Media S.A.. - 1664-302X. ; 14
- Related links:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Antimicrobial resistance (AMR) in Neisseria gonorrhoeae (NG), compromising gonorrhea treatment, is a global public health concern. Improved, quality-assured NG AMR monitoring at the global level is essential. This mini-review examined NG AMR susceptibility surveillance and AMR data from the African continent from 2001 to 2020. Eligible peer-reviewed publications (n = 30) containing NG AMR data for antimicrobials currently recommended for gonorrhea treatment were included. Overall, very limited NG surveillance and AMR data was available. Furthermore, the NG AMR surveillance studies varied greatly regarding surveillance protocols (e.g., populations and samples tested, sample size, antimicrobials examined), methodologies (e.g., antimicrobial susceptibility testing method [agar dilution, minimum inhibitory concentration (MIC) gradient strip test, disc diffusion test] and interpretative criteria), and quality assurance (internal quality controls, external quality assessments [EQA], and verification of AMR detected). Moreover, most studies examined a suboptimal number of NG isolates, i.e., less than the WHO Global Gonococcal Antimicrobial Surveillance Program (GASP) and WHO Enhanced GASP (EGASP) recommendations of ≥100 isolates per setting and year. The notable inter-study variability and frequently small sample sizes make appropriate inter-study and inter-country comparisons of AMR data difficult. In conclusion, it is imperative to establish an enhanced, standardized and quality-assured NG AMR surveillance, ideally including patient metadata and genome sequencing as in WHO EGASP, in Africa, the region with the highest gonorrhea incidence globally. This will enable the monitoring of AMR trends, detection of emerging AMR, and timely refinements of national and international gonorrhea treatment guidelines. To achieve this aim, national and international leadership, political and financial commitments are imperative.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Africa
- Neisseria gonorrhoeae
- WHO Gonococcal Antimicrobial Surveillance Program (GASP)
- WHO enhanced GASP (EGASP)
- antimicrobial resistance
- antimicrobial susceptibility surveillance
- azithromycin
- ceftriaxone
Publication and Content Type
- ref (subject category)
- for (subject category)
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Kakooza, Francis
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Kiggundu, Reuben
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Mboowa, Gerald
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Kateete, Patrick ...
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Nsangi, Olga Ten ...
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Kabahita, Jupite ...
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Ssentalo Bagaya, ...
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Golparian, Danie ...
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Unemo, Magnus, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Frontiers in Mic ...
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Örebro University