Parental death and initiation of antidepressant treatment in surviving children and youth: a national register-based matched cohort study

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Parental death and initiation of antidepressant treatment in surviving children and youth : a national register-based matched cohort study

Liu, Can, 1984- (author): Karolinska Institutet,Stockholms universitet,Institutionen för folkhälsovetenskap

Grotta, Alessandra (author): Stockholms universitet,Institutionen för folkhälsovetenskap

Hiyoshi, Ayako, 1972- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Public Health Sciences, Stockholm University, Stockholm, Sweden; Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden; Department of Epidemiology and Public Health, University College London, London, United Kingdom

Berg, Lisa, 1980- (author): Stockholms universitet,Institutionen för folkhälsovetenskap

Wall-Wieler, Elizabeth (author): Manitoba Centre for Health Policy, University of Manitoba, Canada

Martikainen, Pekka (author): Department of Public Health Sciences, Stockholm University, Stockholm, Sweden; Population Research Unit, Faculty of Social Sciences, University of Helsinki, Finland; Laboratory of Population Health, Max Planck Institute for Demographic Research, Germany

Kawachi, Ichiro (author): Department of Social and Behavioral Sciences, Harvard School of Public Health, United States

Rostila, Mikael, 1977- (author): Stockholms universitet,Institutionen för folkhälsovetenskap

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Elsevier, 2023
2023
English.
In: eClinicalMedicine. - : Elsevier. - 2589-5370. ; 60

Related links:: https://doi.org/10.1...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

BACKGROUND: Population-based longitudinal studies on bereaved children and youth's mental health care use are scarce and few have assessed the role of surviving parents' mental health status.METHODS: Using register data of individuals born in Sweden in 1992-1999, we performed a matched cohort study (n = 117,518) on the association between parental death and subsequent initiation of antidepressant treatment among individuals bereaved at ages 7-24 years. We used flexible parametric survival models to estimate the hazard ratios (HRs) over time after bereavement, adjusting for individual and parental factors. We further examined if the association varied by age at loss, sex, parental sociodemographic factors, cause of death, and the surviving parents' psychiatric care.FINDINGS: The bereaved were more likely to initiate antidepressants treatment than the nonbereaved matched individuals during follow-up (incidence rate per 1000 person years 27.5 [26.5-28.5] vs. 18.2 [17.9-18.6]). The HRs peaked in the first year after bereavement and remained higher than the nonbereaved individuals until the end of the follow-up. The average HR over the 12 years of follow-up was 1.48 (95% confidence interval [1.39-1.58]) for father's death and 1.33 [1.22-1.46] for mother's death. The HRs were particularly high when the surviving parents received psychiatric care before bereavement (2.11 [1.89-2.56] for father's death; 2.14 [1.79-2.56] for mother's death) or treated for anxiety or depression after bereavement (1.80 [1.67-1.94]; 1.82 [1.59-2.07]).INTERPRETATION: The risk of initiating antidepressant treatment was the highest in the first year after parental death and remained elevated over the next decade. The risk was particularly high among individuals with surviving parents affected by psychiatric morbidity.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
SAMHÄLLSVETENSKAP -- Psykologi -- Psykologi (hsv//swe)
SOCIAL SCIENCES -- Psychology -- Psychology (hsv//eng)

Keyword

Antidepressant
Anxiety
Bereavement
Children and youth
Depression
Parental death

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By the author/editor: Liu, Can, 1984-; Grotta, Alessand ...; Hiyoshi, Ayako, ...; Berg, Lisa, 1980 ...; Wall-Wieler, Eli ...; Martikainen, Pek ...; show more...; Kawachi, Ichiro; Rostila, Mikael, ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

SOCIAL SCIENCES: SOCIAL SCIENCES; and Psychology; and Psychology

Articles in the publication: eClinicalMedicin ...

By the university: Örebro University; Stockholm University; Karolinska Institutet

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