Sökning: onr:"swepub:oai:DiVA.org:oru-107612" >
Community carriage ...
Community carriage of ESBL-producing Escherichia coli is associated with strains of low pathogenicity : a Swedish nationwide study
-
- Ny, Sofia (författare)
- Public Health Agency of Sweden, Stockholm, Sweden; Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Stockholm, Sweden
-
- Löfmark, Sonja (författare)
- Public Health Agency of Sweden, Stockholm, Sweden
-
- Börjesson, Stefan, 1979- (författare)
- National Veterinary Institute, Uppsala, Sweden
-
visa fler...
-
- Englund, Stina (författare)
- National Veterinary Institute, Uppsala, Sweden
-
- Ringman, Maj (författare)
- Public Health Agency of Sweden, Stockholm, Sweden
-
- Bergström, Jakob (författare)
- Public Health Agency of Sweden, Stockholm, Sweden
-
- Nauclér, Pontus (författare)
- Karolinska Institutet
-
- Giske, Christian G (författare)
- Karolinska Institutet
-
- Byfors, Sara (författare)
- Public Health Agency of Sweden, Stockholm, Sweden
-
visa färre...
-
(creator_code:org_t)
- 2016-10-24
- 2017
- Engelska.
-
Ingår i: Journal of Antimicrobial Chemotherapy. - : Oxford University Press. - 0305-7453 .- 1460-2091. ; 72:2, s. 582-588
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://academic.oup...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVES: Community carriage of ESBL-producing Escherichia coli (EPE) is common worldwide and there is a need to understand the connection between carriage and infection. We compared the molecular characteristics of EPE among Swedish community carriers with those of EPE causing invasive infections.METHODS: We collected 2134 faecal samples from randomly selected Swedish inhabitants and examined them for the presence of EPE. All participating volunteers answered a questionnaire about putative risk factors for EPE carriage. Suspected EPE isolates (n = 418) from patients with bloodstream infection (BSI) were collected from Swedish laboratories. Isolates were genotypically and phenotypically characterized.RESULTS: Our results show that the EPE population found in carriers generally had lower pathogenicity compared with the isolates from BSIs, since carriers had a lower proportion of E. coli belonging to phylogroup B2, ST131 and ST131 subclone H30-Rx. Isolates from carriers also had lower levels of multiresistance. The Swedish carriage rate of EPE was 4.7% (101/2134) among healthy volunteers. Risk factors associated with carriage were travel to countries in Asia (OR = 3.6, 95% CI = 1.4-9.2) and Africa (OR = 3.6, 95% CI = 1.7-7.7) and a diet without pork (OR = 0.5, 95% CI = 0.3-0.8 for pork eaters).CONCLUSIONS: E. coli host factors previously associated with higher pathogenicity were all more common in BSIs compared with carriers. This indicates that the risk of invasive infection with EPE may be relatively modest in many community carriers and that EPE carriage of high-risk strains should be the focus of attention for prevention.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- spectrum-beta-lactamase
- sequence type st131
- ctx-m
- rapid detection
- chicken meat
- clonal group
- virulence
- infection
- risk
- enterobacteriaceae
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas