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A role for ColV pla...
A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58
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- Reid, Cameron J (author)
- iThree Institute, University of Technology Sydney, Ultimo, NSW, 2007, Australia
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- Cummins, Max L (author)
- iThree Institute, University of Technology Sydney, Ultimo, NSW, 2007, Australia
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- Börjesson, Stefan, 1979- (author)
- Department of Animal Health and Antimicrobial Strategies, National Veterinary Institute (SVA), Uppsala, Sweden; Department of Microbiology, Public Health Agency of Sweden, Solna, Sweden
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- Brouwer, Michael S M (author)
- Wageningen Bioveterinary Research, Lelystad, Netherlands
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- Hasman, Henrik (author)
- Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen S, Denmark
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- Hammerum, Anette M (author)
- Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen S, Denmark
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- Roer, Louise (author)
- Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen S, Denmark
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- Hess, Stefanie (author)
- Institute of Microbiology, Technische Universität Dresden, Dresden, Germany
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- Berendonk, Thomas (author)
- Institute of Hydrobiology, Technische Universität Dresden, Dresden, Germany
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- Nešporová, Kristina (author)
- CEITEC VETUNI, University of Veterinary Sciences Brno, Brno, Czech Republic; Department of Biology and Wildlife Disease, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic
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- Haenni, Marisa (author)
- Université de Lyon-ANSES, Unité Antibiorésistance et Virulence Bactériennes, Lyon, France
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- Madec, Jean-Yves (author)
- Université de Lyon-ANSES, Unité Antibiorésistance et Virulence Bactériennes, Lyon, France
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- Bethe, Astrid (author)
- Institute of Microbiology and Epizootics, Centre for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany; Veterinary Centre for Resistance Research (TZR), Freie Universität Berlin, 14163, Berlin, Germany
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- Michael, Geovana B (author)
- Institute of Microbiology and Epizootics, Centre for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany; Veterinary Centre for Resistance Research (TZR), Freie Universität Berlin, 14163, Berlin, Germany
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- Schink, Anne-Kathrin (author)
- Institute of Microbiology and Epizootics, Centre for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany; Veterinary Centre for Resistance Research (TZR), Freie Universität Berlin, 14163, Berlin, Germany
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- Schwarz, Stefan (author)
- Institute of Microbiology and Epizootics, Centre for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany; Veterinary Centre for Resistance Research (TZR), Freie Universität Berlin, 14163, Berlin, Germany
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- Dolejska, Monika (author)
- CEITEC VETUNI, University of Veterinary Sciences Brno, Brno, Czech Republic; Department of Biology and Wildlife Disease, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic; Biomedical Center, Charles University, Charles, Czech Republic
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- Djordjevic, Steven P (author)
- iThree Institute, University of Technology Sydney, Ultimo, NSW, 2007, Australia
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(creator_code:org_t)
- 2022-02-03
- 2022
- English.
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 13
- Related links:
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https://doi.org/10.1...
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https://www.nature.c...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Escherichia coli ST58 has recently emerged as a globally disseminated uropathogen that often progresses to sepsis. Unlike most pandemic extra-intestinal pathogenic E. coli (ExPEC), which belong to pathogenic phylogroup B2, ST58 belongs to the environmental/commensal phylogroup B1. Here, we present a pan-genomic analysis of a global collection of 752 ST58 isolates from diverse sources. We identify a large ST58 sub-lineage characterized by near ubiquitous carriage of ColV plasmids, which carry genes encoding virulence factors, and by a distinct accessory genome including genes typical of the Yersiniabactin High Pathogenicity Island. This sub-lineage includes three-quarters of all ExPEC sequences in our study and has a broad host range, although poultry and porcine sources predominate. By contrast, strains isolated from cattle often lack ColV plasmids. Our data indicate that ColV plasmid acquisition contributed to the divergence of the major ST58 sub-lineage, and different sub-lineages inhabit poultry, swine and cattle.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Keyword
- extended-spectrum
- multidrug-resistant
- antimicrobial resistance
- p-fimbriae
- enterobacteria
- ceaevirulence
- sequence
- strains
- clones
- surveillance
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Reid, Cameron J
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Cummins, Max L
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Börjesson, Stefa ...
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Brouwer, Michael ...
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Hasman, Henrik
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Hammerum, Anette ...
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show more...
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Roer, Louise
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Hess, Stefanie
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Berendonk, Thoma ...
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Nešporová, Krist ...
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Haenni, Marisa
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Madec, Jean-Yves
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Bethe, Astrid
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Michael, Geovana ...
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Schink, Anne-Kat ...
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Schwarz, Stefan
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Dolejska, Monika
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Djordjevic, Stev ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
- Articles in the publication
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Nature Communica ...
- By the university
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Örebro University