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Genotoxicity of Occ...
Genotoxicity of Occupational Pesticide Exposures among Agricultural Workers in Arab Countries : A Systematic Review and Meta-Analysis
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- Sherif, Moustafa (author)
- Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates
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- Makame, Khadija Ramadhan (author)
- Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary
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- Östlundh, Linda, 1973- (author)
- Örebro universitet,Universitetsbiblioteket
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- Paulo, Marilia Silva (author)
- IPH, CHRC, NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade Nova de Lisboa, 1169-056 Lisbon, Portugal
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- Nemmar, Abderrahim (author)
- Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates
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- Ali, Bassam R. (author)
- Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates
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- Al-Rifai, Rami H. (author)
- Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates
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- Nagy, Károly (author)
- Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary
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- Ádám, Balázs (author)
- Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates
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Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain PO. Box 15551, United Arab Emirates Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary (creator_code:org_t)
- MDPI, 2023
- 2023
- English.
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In: Toxics. - : MDPI. - 2305-6304. ; 11:8
- Related links:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
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- Exposure to pesticides in Arab countries is a significant public health concern due to extensive agricultural activity and pesticide use. This systematic review aimed to evaluate the genotoxic effects of agricultural pesticide exposure in the region, identify research gaps, and assess methodological limitations. Following the PRISMA guidelines, a comprehensive search yielded five relevant studies conducted in Egypt, Syria, and Jordan. Various genotoxicity assays were employed, revealing a higher level of DNA damage in exposed compared to non-exposed individuals. Farmers exposed to pesticides exhibited a significantly higher occurrence of chromosomal translocation (t(14;18)), micronuclei, and chromosomal aberrations. However, only two studies assessed cytotoxicity indirectly. The studies predominantly focused on male participants, with variations in sample size and pesticide types. The lack of detailed exposure data necessitates cautious interpretation. This review underscores the need for further research on the genotoxicity of occupational pesticide exposure in the Middle East. Future studies should adopt robust study designs, collect biological and environmental samples, conduct repeated sampling, analyze seasonal variations, and encompass diverse study sites associated with specific crop groups.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Arab countries
- DNA damage
- agriculture
- genotoxicity
- occupational exposure
- pesticide
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Sherif, Moustafa
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Makame, Khadija ...
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Östlundh, Linda, ...
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Paulo, Marilia S ...
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Nemmar, Abderrah ...
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Ali, Bassam R.
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Al-Rifai, Rami H ...
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Nagy, Károly
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Ádám, Balázs
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Toxics
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Örebro University