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  • Fallet, Manon,1992-IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France (author)

Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-06-04
  • BioMed Central (BMC),2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-108221
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-108221URI
  • https://doi.org/10.1186/s40168-022-01280-5DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies:LabEx "CeMEB" through the Environmental Epigenomics Platform ANR-10-LABX-04-01LabEx "TULIP" ANR-10-LABX-41University of Perpignan Via Domitia ED305Agence Nationale de la Recherche (ANR) ANR-14-CE19-0023
  • Background: The interaction of organisms with their surrounding microbial communities influences many biological processes, a notable example of which is the shaping of the immune system in early life. In the Pacific oyster, Crassostrea gigas, the role of the environmental microbial community on immune system maturation — and, importantly, protection from infectious disease — is still an open question.Results: Here, we demonstrate that early life microbial exposure durably improves oyster survival when challenged with the pathogen causing Pacific oyster mortality syndrome (POMS), both in the exposed generation and in the subsequent one. Combining microbiota, transcriptomic, genetic, and epigenetic analyses, we show that the microbial exposure induced changes in epigenetic marks and a reprogramming of immune gene expression leading to long-term and intergenerational immune protection against POMS.Conclusions: We anticipate that this protection likely extends to additional pathogens and may prove to be an important new strategy for safeguarding oyster aquaculture efforts from infectious disease

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  • Montagnani, CarolineIfremer, UBO CNRS IRD, LEMAR UMR 6539, Argenton, France (author)
  • Petton, BrunoIfremer, UBO CNRS IRD, LEMAR UMR 6539, Argenton, France (author)
  • Dantan, LucIHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France (author)
  • de Lorgeril, JulienIHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France; Ifremer, IRD, Univ Nouvelle‑Calédonie, Univ La Réunion, ENTROPIE, Nouméa, Nouvelle‑Calédonie, France (author)
  • Comarmond, SébastienIHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France (author)
  • Chaparro, CristianIHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France (author)
  • Toulza, EveIHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France (author)
  • Boitard, SimonCBGP, CIRAD, INRAE, Institut Agro, IRD, Université de Montpellier, Montpellier, France (author)
  • Escoubas, Jean-MichelIHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France (author)
  • Vergnes, AgnèsIHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France (author)
  • Le Grand, JacquelineIfremer, UBO CNRS IRD, LEMAR UMR 6539, Argenton, France (author)
  • Bulla, IngoIHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France (author)
  • Gueguen, YannickIHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France; MARBEC, CNRS, Ifremer, IRD, Univ Montpellier, Sète, France (author)
  • Vidal-Dupiol, JérémieIHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France (author)
  • Grunau, ChristophIHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France (author)
  • Mitta, GuillaumeIHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France; Ifremer, UMR 241 Écosystèmes Insulaires Océaniens, Labex Corail, Centre Ifremer du Pacifique, Tahiti, French Polynesia (author)
  • Cosseau, CélineIHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France (author)
  • IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, FranceIfremer, UBO CNRS IRD, LEMAR UMR 6539, Argenton, France (creator_code:org_t)

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  • In:Microbiome: BioMed Central (BMC)10:12049-2618

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