Search: onr:"swepub:oai:DiVA.org:oru-109511" >
The cascade of care...
The cascade of care for patients with chronic hepatitis delta in Southern Stockholm, Sweden for the past 30 years
-
- Kamal, Habiba (author)
- Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden
-
- Lindahl, Karin (author)
- Karolinska Institutet
-
- Ingre, Michael (author)
- Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden; Centre for Bioinformatics and Biostatistics, Karolinska Institute, Stockholm, Sweden
-
show more...
-
- Gahrton, Caroline (author)
- Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden
-
- Karkkonen, Kerstin (author)
- Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden
-
- Nowak, Piotr (author)
- Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden
-
- Vesterbacka, Jan (author)
- Karolinska Institutet
-
- Stål, Per (author)
- Karolinska Institutet
-
- Wedemeyer, Heiner (author)
- Department of Gastroenterology and Hepatology, University of Hannover, Hannover, Germany
-
- Duberg, Ann-Sofi, Docent, 1957- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
-
- Aleman, Soo (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- Wiley-Blackwell Publishing Inc. 2024
- 2024
- English.
-
In: Liver international. - : Wiley-Blackwell Publishing Inc.. - 1478-3223 .- 1478-3231. ; 44:1, s. 228-240
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND AND AIMS: Previous studies have shown suboptimal screening for hepatitis D virus (HDV) among patients with chronic hepatitis B (CHB). This study presents the cascade of care for HDV infection in a major secondary referral centre in Southern Stockholm, Sweden.METHODS: HBsAg+ve patients attending Karolinska University Hospital (KUH) from 1992 to 2022 were identified. The prevalence of anti-HDV and/or HDV RNA positivity, interferon (IFN) therapy and maintained virological responses (MVR) after HDV treatment were assessed. Also, time to anti-HDV testing was analysed in relation to liver-related outcomes with logistic regression.RESULTS: Among 4095 HBsAg+ve persons, 3703 (90.4%) underwent an anti-HDV screening; within a median of 1.8 months (range 0.0-57.1) after CHB diagnosis. This screening rate increased over time, to 97.9% in the last decade. Overall, 310 (8.4%) were anti-HDV+ve, of which 202 (65.2%) were HDV RNA+ve. Eighty-five (42%) received IFN, and 9 (10.6%) achieved MVR at the last follow-up. The predictive factors for anti-HDV screening were Asian origin, diagnosis after the year 2012, HIV co-infection (negative factor) and HBV DNA level < 2000 IU/mL in univariable analysis, while HIV co-infection was the only remaining factor in multivariable analysis. Delayed anti-HDV test >5 years was independently associated with worsened liver-related outcomes (adjusted odds ratio = 7.6, 95% CI 1.8-31.6).CONCLUSION: Higher frequency of HDV screening than previously published data could be seen among CHB patients at KUH in a low-endemic setting. Receiving a delayed screening test seems to be associated with worse outcomes, stressing the need of a strategy for timely HDV diagnosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- HBV
- HDV
- HIV
- cascade of care
- hepatitis delta
- screening
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Kamal, Habiba
-
Lindahl, Karin
-
Ingre, Michael
-
Gahrton, Carolin ...
-
Karkkonen, Kerst ...
-
Nowak, Piotr
-
show more...
-
Vesterbacka, Jan
-
Stål, Per
-
Wedemeyer, Heine ...
-
Duberg, Ann-Sofi ...
-
Aleman, Soo
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Liver internatio ...
- By the university
-
Örebro University
-
Karolinska Institutet