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Proteome-wide survey of the autoimmune target repertoire in autoimmune polyendocrine syndrome type 1

Landegren, Nils (author)
Uppsala universitet,Karolinska Institutet,Autoimmunitet,Science for Life Laboratory, SciLifeLab,Karolinska Institute, Sweden; Uppsala University, Sweden
Sharon, Donald (author)
Department of Genetics, Stanford University, California, USA; Department of Molecular, Cellular, and Developmental Biology, Yale University, Connecticut, USA,Stanford University, CA 94305 USA; Yale University, CT 06520 USA
Freyhult, Eva (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerfarmakologi och beräkningsmedicin,Uppsala University, Sweden; Uppsala University, Sweden
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Hallgren, Åsa (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Karolinska Institute, Sweden; Uppsala University, Sweden
Eriksson, Daniel (author)
Uppsala universitet,Karolinska Institutet,Science for Life Laboratory, SciLifeLab,Karolinska Institute, Sweden; Uppsala University, Sweden
Edqvist, Per-Henrik (author)
Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden; Science Life Lab, Sweden
Bensing, Sophie (author)
Karolinska Institutet,Karolinska Institute, Sweden
Wahlberg, Jeanette, 1969- (author)
Linköpings universitet,Medicinska fakulteten,Avdelningen för kardiovaskulär medicin,Region Östergötland, Endokrinmedicinska kliniken
Nelson, Lawrence M. (author)
Integrative Reproductive Medicine Group, Intramural Research Program on Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, USA,NICHHD, MD 20892 USA
Gustafsson, Jan (author)
Uppsala universitet,Pediatrik,Uppsala University, Sweden
Husebye, Eystein S. (author)
Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway
Anderson, Mark S. (author)
Diabetes Center, University of California San Francisco, USA,University of Calif San Francisco, CA 94143 USA
Snyder, Michael (author)
Department of Genetics, Stanford University, California, USA,Stanford University, CA 94305 USA
Kämpe, Olle (author)
Uppsala universitet,Karolinska Institutet,Science for Life Laboratory, SciLifeLab,Autoimmunitet,Karolinska Institute, Sweden; Uppsala University, Sweden
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 (creator_code:org_t)
2016-02-01
2016
English.
In: Scientific Reports. - : Springer Nature. - 2045-2322. ; 6
Related links:
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Autoimmune polyendocrine syndrome type 1 (APS1) is a monogenic disorder that features multiple autoimmune disease manifestations. It is caused by mutations in the Autoimmune regulator (AIRE) gene, which promote thymic display of thousands of peripheral tissue antigens in a process critical for establishing central immune tolerance. We here used proteome arrays to perform a comprehensive study of autoimmune targets in APS1. Interrogation of established autoantigens revealed highly reliable detection of autoantibodies, and by exploring the full panel of more than 9000 proteins we further identified MAGEB2 and PDILT as novel major autoantigens in APS1. Our proteome-wide assessment revealed a marked enrichment for tissue-specific immune targets, mirroring AIRE's selectiveness for this category of genes. Our findings also suggest that only a very limited portion of the proteome becomes targeted by the immune system in APS1, which contrasts the broad defect of thymic presentation associated with AIRE-deficiency and raises novel questions what other factors are needed for break of tolerance.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences (hsv//eng)

Keyword

autoimmune

Publication and Content Type

ref (subject category)
art (subject category)

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