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Short duration of b...
Short duration of breast-feeding as a risk-factor for beta-cell autoantibodies in 5-year-old children from the general population
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- Holmberg, Hanna (author)
- Division of Paediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Linköpings Universitet, Linköping, Sweden
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- Wahlberg, Jeanette, 1969- (author)
- Division of Paediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Linköpings Universitet, Linköping, Sweden
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- Vaarala, Outi (author)
- Division of Paediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Linköpings Universitet, Linköping, Sweden; Department of Viral Diseases and Immunology, Laboratory for Immunobiology, National Public Health Institute, Helsinki, Finland
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- Ludvigsson, Johnny (author)
- Division of Paediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Linköpings Universitet, Linköping, Sweden
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ABIS Study Group, - (contributor)
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(creator_code:org_t)
- Cambridge University Press, 2007
- 2007
- English.
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In: British Journal of Nutrition. - : Cambridge University Press. - 0007-1145 .- 1475-2662. ; 97:1, s. 111-116
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Breast-feeding has been suggested to have a protective effect against the development of type 1 diabetes. In the present study, we investigated the relation between duration of breast-feeding and beta-cell autoantibodies in 5-year-old non-diabetic children who participated in a prospective population-based follow-up study (the All Babies in Southeast Sweden study). Autoantibodies to insulin (IAA), glutamic acid decarboxylase (GADA) and the protein tryosine phosphatase-like IA-2 (IA-2A) were measured by radiobinding assays. A short duration of total breast-feeding was associated with an increased risk of GADA and/or IAA above the ninety-fifth percentile at 5 years of age (OR 2.09, 95% CI 1.45, 3.02; P<0.000) as well as with an increased risk of IAA above the ninety-fifth percentile at this age (OR 2.89, 95% CI 1.81, 4.62, P<0.000). A short duration of exclusive breast-feeding was associated with an increased risk of GADA, IAA and/or IA-2A above the ninety-ninth percentile (OR 2.01, 95% CI 1.08, 3.73; P=0.028) as well as with an increased risk of IA-2A above the ninety-ninth percentile (OR 3.50, 95% CI 1.38, 8.92, P=0.009) at 5 years of age. An early introduction of formula was associated with an increased risk of GADA, IAA and/or IA-2A above the ninety-ninth percentile (OR 1.84, 95% CI 1.01, 3.37; P=0.047) at 5 years of age. The positive association between a short duration of both total and exclusive breast-feeding, as well as an early introduction of formula, and positivity for beta-cell autoantibodies in children from the general population suggest that breast-feeding modifies the risk of beta-cell autoimmunity, even years after finishing breast-feeding.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Breast-feeding
- β-cell autoantibodies
- Children
- General population
Publication and Content Type
- ref (subject category)
- art (subject category)
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