SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:oru-110346"
 

Search: onr:"swepub:oai:DiVA.org:oru-110346" > Altered biomarkers ...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00010380naa a2200817 4500
001oai:DiVA.org:oru-110346
003SwePub
008231215s2023 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-217965
009oai:prod.swepub.kib.ki.se:154000224
009oai:DiVA.org:liu-198960
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1103462 URI
0247 a https://doi.org/10.1093/ejendo/lvad1362 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2179652 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1540002242 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1989602 URI
040 a (SwePub)orud (SwePub)umud (SwePub)kid (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Saevik, Ase Bjorvatnu Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway,Univ Bergen, Norway; Univ Bergen, Norway4 aut
2451 0a Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study
264 1b Bioscientifica,c 2023
338 a print2 rdacarrier
500 a Funding Agencies:Research Council of NorwayNovo Nordisk FoundationInternal Medicine Association of NorwayUniversity of BergenWestern Regional Health AuthoritiesDepartment of Medicine and Hormone LaboratoryHaukeland University HospitalStockholm County CouncilKarolinska Institutet
500 a Funding Agencies|Research Council of Norway [288022]; Novo Nordisk Foundation [NNF18OC0034130]; Internal Medicine Association of Norway; University of Bergen; Western Regional Health Authorities; Department of Medicine and Hormone Laboratory , Haukeland University Hospital; Stockholm County Council; Karolinska Institutet
520 a Objective: Increased prevalence of cardiovascular disease has been reported in autoimmune Addisons disease (AAD), but pathomechanisms are poorly understood.Design: Cross-sectional study.Methods: We compared serum levels of 177 cardiovascular and inflammatory biomarkers in 43 patients with AAD at >18-h glucocorticoid withdrawal and 43 matched controls, overall and stratified for sex. Biomarker levels were correlated with the frequency of adrenal crises and quality of life (QoL) by AddiQoL-30. Finally, we investigated changes in biomarker levels following 250 mu g tetracosactide injection in patients without residual adrenocortical function (RAF) to explore glucocorticoid-independent effects of high ACTH.Results: Nineteen biomarkers significantly differed between patients with AAD and controls; all but 1 (ST1A1) were higher in AAD. Eight biomarkers were significantly higher in female patients compared with controls (IL6, MCP1, GAL9, SPON2, DR4, RAGE, TNFRSF9, and PGF), but none differed between male patients and controls. Levels of RAGE correlated with the frequency of adrenal crises (r = 0.415, P = .006) and AddiQoL-30 scores (r = -0.347, P = .028) but not after correction for multiple testing. PDL2 and leptin significantly declined 60 min after injection of ACTH in AAD without RAF (-0.15 normalized protein expression [NPX], P = .0001, and -0.25 NPX, P = .0003, respectively).Conclusions: We show that cardiovascular and inflammatory biomarkers are altered in AAD compared with controls, particularly in women. RAGE might be a marker of disease severity in AAD, associated with more adrenal crises and reduced QoL. High ACTH reduced PDL2 and leptin levels in a glucocorticoid-independent manner but the overall effect on biomarker profiles was small.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a Autoimmunity
653 a primary adrenal insufficiency
653 a cardiovascular disease
653 a proteomics
653 a biomarkers
7001 a Ueland, Gretheu Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Norway; Haukeland Hosp, Norway4 aut
7001 a Akerman, Anna-Karinu Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Medicine, Örebro University Hospital, Örebro, Sweden,Karolinska Inst, Sweden; Orebro Univ Hosp, Sweden4 aut
7001 a Methlie, Paalu Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Norway; Haukeland Hosp, Norway4 aut
7001 a Quinkler, Marcusu Practice for Endocrinology and Nephrology, Endocrinology in Charlottenburg, Berlin, Germany,Endocrinol Charlottenburg, Germany4 aut
7001 a Jorgensen, Anders Palmstromu Department of Endocrinology, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Norway4 aut
7001 a Hoybye, Charlotteu Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden4 aut
7001 a Wahlberg, Jeanetteu Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken4 aut0 (Swepub:liu)jeawa98
7001 a Nedrebo, Bjorn Gunnaru Department of Internal Medicine, Haugesund Hospital, Haugesund, Norway,Haugesund Hosp, Norway4 aut
7001 a Dahle, Anne Liseu Department of Internal Medicine, Haugesund Hospital, Haugesund, Norway,Haugesund Hosp, Norway4 aut
7001 a Carlsen, Siriu Department of Endocrinology, Stavanger University Hospital, Stavanger, Norway,Stavanger Univ Hosp, Norway4 aut
7001 a Tomkowicz, Anetau Department of Medicine, Sørlandet Hospital, Kristiansand, Norway,Sorlandet Hosp, Norway4 aut
7001 a Sollid, Stina Thereseu Department of Medicine, Drammen Hospital, Vestre Viken Health Trust, Drammen, Norway,Drammen Hosp, Norway4 aut
7001 a Nermoen, Ingridu Department of Endocrinology, Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Norway4 aut
7001 a Gronning, Kajau Department of Endocrinology, Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Norway4 aut
7001 a Dahlqvist, Peru Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Umea Univ, Sweden4 aut0 (Swepub:umu)perdat96
7001 a Grimnes, Guriu Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway; Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT the Arctic University of Norway, Tromsø, Norway,Univ Hosp North Norway, Norway; UiT Arctic Univ Norway, Norway4 aut
7001 a Skov, Jakobu Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden4 aut
7001 a Finnes, Trineu Section of Endocrinology, Innlandet Hospital Trust, Hamar, Norway,Innlandet Hosp Trust, Norway4 aut
7001 a Valland, Susanna F.u Section of Endocrinology, Innlandet Hospital Trust, Hamar, Norway,Innlandet Hosp Trust, Norway4 aut
7001 a Wahlberg, Jeanette,d 1969-u Linköping University, Linköping, Sweden4 aut0 (Swepub:oru)jewg
7001 a Holte, Synnove Emblemu Department of Medicine, Sørlandet Hospital, Arendal, Norway,Sorlandet Hosp, Norway4 aut
7001 a Kampe, Olleu K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Univ Bergen, Norway; Karolinska Inst, Sweden4 aut
7001 a Bensing, Sophieu Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden,Karolinska Inst, Sweden4 aut
7001 a Husebye, Eystein Sverreu Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway; Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Univ Bergen, Norway; Haukeland Hosp, Norway; Karolinska Inst, Sweden4 aut
7001 a Oksnes, Marianneu Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway; Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Univ Bergen, Norway; Haukeland Hosp, Norway; Karolinska Inst, Sweden4 aut
7102 a Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norwayb Univ Bergen, Norway; Univ Bergen, Norway4 org
7730 t European Journal of Endocrinologyd : Bioscientificag 189:4, s. 438-447q 189:4<438-447x 0804-4643x 1479-683X
8564 u https://doi.org/10.1093/ejendo/lvad136y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1819663/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-110346
8564 8u https://doi.org/10.1093/ejendo/lvad136
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-217965
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:154000224
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-198960

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view