onr:"swepub:oai:DiVA.org:oru-110909"
Search: onr:"swepub:oai:DiVA.org:oru-110909" > Age-specific and se...
- 1 of 1
- Previous record
- Next record
- To hitlist
Age-specific and sex-specific risks for HCC in African-born persons with chronic hepatitis B without cirrhosis
-
- Kamal, Habiba (author)
- Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden; Centre for Bioinformatics and Biostatistics, Karolinska Institute, Stockholm, Sweden
-
- Ingre, Michael (author)
- Centre for Bioinformatics and Biostatistics, Karolinska Institute, Stockholm, Sweden; Department of Upper GI Diseases, Karolinska University Hospital, Stockholm, Sweden
-
- Stål, Per (author)
- Centre for Bioinformatics and Biostatistics, Karolinska Institute, Stockholm, Sweden; Department of Medical Sciences, Section of Infectious diseases, Uppsala University, Uppsala Sweden
- show more...
- show less...
- (creator_code:org_t)
- Wiley Periodicals Inc. on behalf of the American Association for the Study of Liver Diseases, 2023
- 2023
- English.
- In: Hepatology communications. - : Wiley Periodicals Inc. on behalf of the American Association for the Study of Liver Diseases. - 2471-254X. ; 7:12
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- BACKGROUND: The international recommendations of HCC surveillance for African-born persons with chronic hepatitis B (CHB) without cirrhosis are divergent, probably due to scarce data on incidence rate (IR) for HCC.METHODS: We assembled a cohort with prospectively collected data of Swedish residents of African origin with diagnosed CHB without cirrhosis at baseline from 1990 to 2015. Data from nationwide registers were used to calculate the sex-specific IR and IR ratio (incidence rate ratios) in relation to age, comorbidities, and birth region, using a generalized linear model with a log-link function and Poisson distribution.RESULTS: Among 3865 African-born persons with CHB without cirrhosis at baseline, 31 (0.8%; 77.4% men) developed HCC during a median of 11.1 years of follow-up, with poor survival after HCC diagnosis. The mean age at HCC diagnosis was 46.8 (SD±14.7; range 23-79) in men. HCC IR exceeded the recommended surveillance threshold of 0.2%/year at ages 54 and 59 years in men and women, respectively, and at ages 20-40 years if HCV or HDV co-infection was present. African-born men with CHB had an incidence rate ratios of 10.6 (95% CI 4.4-31.5) for HCC compared to matched African-born peers without CHB, and an incidence rate ratios of 35.3 (95% CI 16.0-88.7) compared to a matched general population.CONCLUSIONS: African-born men with CHB without cirrhosis reached an IR of 0.2%/year between 50 and 60 years, and at younger ages if HCV or HDV co-infection was present. Our findings need further confirmation, and new cost-effectiveness analyses specific for young populations are needed, to provide personalized and cost-effective HCC surveillance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Infektionssjukdomar
- Infectious Diseases
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Hepatology communications (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Kamal, Habiba
- Ingre, Michael
- Stål, Per
- Westman, Gabriel
- Bruce, Daniel
- Wedemeyer, Heine ...
- show more...
- Duberg, Ann-Sofi ...
- Aleman, Soo
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Infectious Medic ...
- Articles in the publication
- Hepatology commu ...
- By the university
- Örebro University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
