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  • Yuan, Bo,1985-Stockholms universitet,Institutionen för miljövetenskap,Norwegian University of Science and Technology, Norway (author)

Polychlorinated alkanes in paired blood serum and breast milk in a Swedish cohort study : Matrix dependent partitioning differences compared to legacy POPs

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • Elsevier,2024
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:oru-111020
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-111020URI
  • https://doi.org/10.1016/j.envint.2024.108440DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-220474URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-227312URI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • BACKGROUND: Polychlorinated alkanes (PCAs) constitute a large group of individual congeners originating from commercial chlorinated paraffin (CP) products with carbon chain lengths of PCAs-C10-13, PCAs-C14-17, and PCAs-C18-32, occasionally containing PCAs-C6-9 impurities. The extensive use of CPs has led to global environmental pollution of PCAs. This study aimed to quantify PCAs in paired serum and breast milk of lactating Swedish mothers, exploring their concentration relationship.METHODS: Twenty-five paired samples of mothers' blood serum and breast milk were analysed and concentrations were determined for PCAs C6-32 and compared to 4,4'-DDE, the PCB congener 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153), and hexachlorobenzene (HCB).RESULTS: The median concentrations of PCAs-C6-9, PCAs-C10-13, PCAs-C14-17, PCAs-C18-32 and ΣPCAs in serum were 14, 790, 520, 16 and 1350 ng/g lipid weight (lw), respectively, and in breast milk 0.84, 36, 63, 6.0 and 107 ng/g lw. Levels of 4,4'-DDE, CB-153 and HCB were comparable in the two matrices, serum and breast milk at 17, 12 and 4.9 ng/g lw. The results show significant differences of PCAs-C10-13 and PCAs-C14-17 in breast milk with 22- and 6.2-times lower lw-based concentrations than those measured in serum. On wet weight the differences serum/breast milk ratios of PCAs-C6-9, PCAs-C10-13, PCAs-C14-17, PCAs-C18-32 and ΣPCAs were 1.7, 3.2, 1.0, 0.4 and 1.6, respectively, while the ratio for 4,4'-DDE, CB-153 and HCB were each close to 0.1.CONCLUSION: Swedish lactating mothers had high serum concentrations of PCAs-C10-13 and PCAs-C14-17, with the ΣPCAs median serum concentration of 1350 ng/g lw. The breast milk concentration, although considerably lower at 107 ng/g lw, still surpassed those of 4,4'-DDE, CB-153 and HCB, suggesting an exposure risk of infants to PCAs. The variation in blood and breast milk accumulation between PCAs and studied legacy POPs, is rarely discussed but warrants further studies on partitioning properties as well as associated toxicological implications.

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  • Bignert, AndersThe Swedish Museum of Natural History, SE-104 01, Stockholm, Sweden (author)
  • Andersson, Patrik L.Umeå universitet,Kemiska institutionen(Swepub:umu)paan0001 (author)
  • West, Christina E.Umeå universitet,Institutionen för klinisk vetenskap(Swepub:umu)chwe0024 (author)
  • Domellöf, Magnus,1963-Umeå universitet,Institutionen för klinisk vetenskap(Swepub:umu)mado0002 (author)
  • Bergman, Åke,1950-Stockholms universitet,Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Environmental Science (ACES), Stockholm University, SE-106 92, Stockholm, Sweden,Department of Environmental Science (ACES), Stockholm University, Stockholm, Sweden; Department of Science and Technology, Örebro University, Örebro, Sweden,Institutionen för miljövetenskap(Swepub:su)alb (author)
  • Stockholms universitetInstitutionen för miljövetenskap (creator_code:org_t)

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  • In:Environment International: Elsevier1830160-41201873-6750

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