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Risk of Psychosis A...
Risk of Psychosis Among Individuals Who Have Presented to Hospital With Self-harm : A Prospective Nationwide Register Study in Sweden
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- Bolhuis, Koen (author)
- Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands; Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Ghirardi, Laura (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; MediNeos Observational Research-IQVIA, Data Management & Statistics, Modena, Italy
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- Kuja-Halkola, Ralf (author)
- Karolinska Institutet
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- Lång, Ulla (author)
- Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Finnish Institute for Health and Welfare, Helsinki, Finland; University of Oulu, School of Medicine, Oulu, Finland
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- Martin, Cederlöf, 1980- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Metsala, Johanna (author)
- Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Finnish Institute for Health and Welfare, Helsinki, Finland
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- Corcoran, Paul (author)
- National Suicide Research Foundation, University College Cork, Cork, Ireland; School of Public Health, University College Cork, Cork, Ireland
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- O'Connor, Karen (author)
- Rise, South Lee Mental Health Services, Cork & Department of Psychiatry, University College Cork, Cork, Ireland; National Clinical Programme for Early Intervention in Psychosis, Health Service Executive Dublin, Dublin, Ireland
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- Dodd, Philip (author)
- National Office for Suicide Prevention, Health Service Executive Dublin, Dublin, Ireland
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- Larsson, Henrik, 1975- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Kelleher, Ian (author)
- Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; University of Oulu, School of Medicine, Oulu, Finland; University College Dublin, School of Medicine, Dublin, Ireland
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Schizophrenia Bulletin. - : Oxford University Press. - 0586-7614 .- 1745-1701.
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- BACKGROUND AND HYPOTHESIS: Recent research showed that young people who presented to hospital with self-harm in Finland had a significantly elevated risk of later psychosis. We investigated the prospective relationship between hospital presentation for self-harm and risk of psychosis in an unprecedentedly large national Swedish cohort.STUDY DESIGN: We used inpatient and outpatient healthcare registers to identify all individuals born between 1981 and 1993 who were alive and living in Sweden on their 12th birthday and who presented to hospital one or more times with self-harm. We compared them with a matched cohort, followed up for up to 20 years, and compared the cumulative incidence of psychotic disorders. Furthermore, we examined whether the strength of the relationship between hospital presentation for self-harm and later psychosis changed over time by examining for cohort effects.STUDY RESULTS: In total, 28 908 (2.0%) individuals presented to hospital with self-harm without prior psychosis diagnosis during the follow-up. For individuals who presented to hospital with self-harm, the cumulative incidence of diagnosed psychosis was 20.7% at 20 years follow-up (hazard radio = 13.9, 95% CI 13.3-14.6, P-value <5 × 10-308). There was no evidence of a dilution of the effect over time: while the incidence of hospital self-harm presentation increased, this did not result in an attenuation over time of the strength of the relationship between hospital self-harm presentation and subsequent psychosis.CONCLUSIONS: Individuals who present to hospital with self-harm in their teens and 20s represent an important risk group for psychosis prediction and prevention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Bipolar disorder
- prediction
- register
- schizophrenia
- self-harm
- suicide
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bolhuis, Koen
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Ghirardi, Laura
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Kuja-Halkola, Ra ...
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Lång, Ulla
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Martin, Cederlöf ...
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Metsala, Johanna
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Corcoran, Paul
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O'Connor, Karen
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Dodd, Philip
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Larsson, Henrik, ...
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Kelleher, Ian
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Schizophrenia Bu ...
- By the university
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Örebro University
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Karolinska Institutet