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SCOTROC 2B :
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Clamp, A. R.
(författare)
SCOTROC 2B : feasibility of carboplatin followed by docetaxel or docetaxel-irinotecan as first-line therapy for ovarian cancer
- Artikel/kapitelEngelska2006
Förlag, utgivningsår, omfång ...
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2005-12-13
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Springer Science and Business Media LLC,2006
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-11114
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-11114URI
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https://doi.org/10.1038/sj.bjc.6602910DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The feasibility of combination irinotecan, carboplatin and docetaxel chemotherapy as first-line treatment for advanced epithelial ovarian carcinoma was assessed. One hundred patients were randomised to receive four 3-weekly cycles of carboplatin (area under the curve (AUC) 7) followed by four 3-weekly cycles of docetaxel 100 mg m(-2) (arm A, n=51) or docetaxel 60 mg m(-2) with irinotecan 200 mg m(-2) (arm B, n=49). Neither arm met the formal feasibility criterion of an eight-cycle treatment completion rate that was statistically greater than 60% (arm A 71% (90% confidence interval (CI) 58-81%; P=0.079; arm B 67% (90% CI 55-78%; P=0.184)). Median-dose intensities were >85% of planned dose for all agents. In arms A and B, 15.6 and 12.2% of patients, respectively, withdrew owing to treatment-related toxicity. Grade 3-4 sensory neurotoxicity was more common in arm A (1.9 vs 0%) and grade 3-4 diarrhoea was more common in arm B (0.6 vs 3.5%). Of patients with radiologically evaluable disease at baseline, 50 and 48% responded to therapy in arms A and B, respectively; at median 17.1 months' follow-up, median progression-free survival was 17.1 and 15.9 months, respectively. Although both arms just failed to meet the formal statistical feasibility criteria, the observed completion rates of around 70% were reasonable. The addition of irinotecan to first-line carboplatin and docetaxel chemotherapy was generally well tolerated although associated with increased gastrointestinal toxicity. Further exploratory studies of topoisomerase-I inhibitors in this setting may be warranted.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mäenpää, J.
(författare)
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Cruickshank, D.
(författare)
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Ledermann, J.
(författare)
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Wilkinson, P. M.
(författare)
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Welch, R.
(författare)
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Chan, S.
(författare)
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Vasey, P.
(författare)
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Sorbe, BengtÖrebro universitet,Institutionen för klinisk medicin(Swepub:oru)bse
(författare)
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Hindley, A.
(författare)
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Jayson, G. C.
(författare)
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Örebro universitetInstitutionen för klinisk medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British Journal of Cancer: Springer Science and Business Media LLC94:1, s. 55-610007-09201532-1827
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Till lärosätets databas
- Av författaren/redakt...
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Clamp, A. R.
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Mäenpää, J.
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Cruickshank, D.
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Ledermann, J.
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Wilkinson, P. M.
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Welch, R.
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visa fler...
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Chan, S.
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Vasey, P.
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Sorbe, Bengt
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Hindley, A.
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Jayson, G. C.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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British Journal ...
- Av lärosätet
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Örebro universitet