Blood biomarkers for traumatic brain injury: A narrative review of current evidence

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Hossain, IftakherKarolinska Institute,Turku University Hospital,University of Cambridge (author)

Blood biomarkers for traumatic brain injury : A narrative review of current evidence

Article/chapterEnglish2024

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Elsevier,2024
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LIBRIS-ID:oai:DiVA.org:oru-111346
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-111346URI
https://doi.org/10.1016/j.bas.2023.102735DOI
https://lup.lub.lu.se/record/82008929-2e17-471e-9216-df461a18faebURI

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Language:English
Summary in:English

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Subject category:for swepub-publicationtype

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Funding: The Finnish Medical Foundation (IH), The Päivikki and Sakari Sohlberg Foundation (IH), The Paulo Foundation (IH), The Finnish Cultural Foundation (IH), Skåne University Hospital ALF funds (NM), Hans-Gabriel af Trolle Wachtmeister Foundation (NM) and Swedish Brain Foundation (NM).
Introduction: A blood-based biomarker (BBBM) test could help to better stratify patients with traumatic brain injury (TBI), reduce unnecessary imaging, to detect and treat secondary insults, predict outcomes, and monitor treatment effects and quality of care.Research question: What evidence is available for clinical applications of BBBMs in TBI and how to advance this field?Material and methods: This narrative review discusses the potential clinical applications of core BBBMs in TBI. A literature search in PubMed, Scopus, and ISI Web of Knowledge focused on articles in English with the words "traumatic brain injury" together with the words "blood biomarkers", "diagnostics", "outcome prediction", "extracranial injury" and "assay method" alone-, or in combination.Results: Glial fibrillary acidic protein (GFAP) combined with Ubiquitin C-terminal hydrolase-L1(UCH-L1) has received FDA clearance to aid computed tomography (CT)-detection of brain lesions in mild (m) TBI. Application of S100B led to reduction of head CT scans. GFAP may also predict magnetic resonance imaging (MRI) abnormalities in CT-negative cases of TBI. Further, UCH-L1, S100B, Neurofilament light (NF-L), and total tau showed value for predicting mortality or unfavourable outcome. Nevertheless, biomarkers have less role in outcome prediction in mTBI. S100B could serve as a tool in the multimodality monitoring of patients in the neurointensive care unit.Discussion and conclusion: Largescale systematic studies are required to explore the kinetics of BBBMs and their use in multiple clinical groups. Assay development/cross validation should advance the generalizability of those results which implicated GFAP, S100B and NF-L as most promising biomarkers in the diagnostics of TBI.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
Traumatic brain injury
Blood biomarkers
Diagnostics
Outcome prediction
Blood biomarkers
Diagnostics
Outcome prediction
Traumatic brain injury

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Marklund, NiklasLund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUBIN Lab- Lunds laboratorium för neurokirurgisk hjärnskadeforskning,Forskargrupper vid Lunds universitet,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,LUBIN Lab- Lund Brain Injury laboratory for Neurosurgical research,Lund University Research Groups(Swepub:lu)ni0588ma (author)
Czeiter, EndreDepartment of Neurosurgery, Medical School, Neurotrauma Research Group, Szentagothai Research Centre, And HUN-REN-PTE Clinical Neuroscience MR Research Group, University of Pecs, Pecs, Hungary (author)
Hutchinson, PeterDepartment of Clinical Neurosciences, Neurosurgery Unit, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom (author)
Büki, Andras,1966-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurosurgery(Swepub:oru)asbi (author)
Karolinska InstituteTurku University Hospital (creator_code:org_t)

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