SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:oru-111908"
 

Search: onr:"swepub:oai:DiVA.org:oru-111908" > Gastrointestinal ca...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Vujasinovic, MiroslavDepartment of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Karolinska institutet, Stockholm, Sweden (author)

Gastrointestinal cancer precursor risk and mortality in pancreatic intraductal papillary mucinous neoplasms : a nationwide cohort study

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • Taylor & Francis,2024
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-111908
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-111908URI
  • https://doi.org/10.1080/00365521.2024.2310162DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:154938866URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background and aims: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a precursor of pancreatic cancer. While earlier research has shown a high prevalence of synchronous/metachronous extrapancreatic tumors in IPMN patients, these studies have often been small with retrospective data collection. The aim of the study was to examine absolute and relative risks of non-pancreatic gastrointestinal (GI) cancer precursors and mortality in histologically confirmed IPMN.Methods: Through the nationwide ESPRESSO histopathology cohort, we retrieved data on IPMN between 1965 and 2016. Each index case was matched to <= 5 general population controls. Through Cox regression, we estimated hazard ratios (HRs) for future GI cancer precursors and death.Results: A total of 117 patients with IPMN and 539 age- and sex-matched controls were included. Over a median of 2.1 years of follow up, we confirmed two (1.7%) incident GI cancer precursors in IPMN vs. four (0.7%) in controls, corresponding to an HR of 1.89 (95%CI = 0.34-10.55). By contrast, IPMN patients were at increased risk of death (HR 3.61 (95%CI = 1.79-7.27)). The most common cause of death in IPMN was pancreatic cancer (n = 14; 45.2% of all deaths).Conclusions: We found no association between IPMN and other GI cancer precursors. This argues against comprehensive routine surveillance for other GI cancer precursors in IPMN patients. Mortality was increased in IPMN with pancreatic cancer being the most common cause of death, indicating the need for lifelong follow up in all resected and non-resected patients with IPMN. However, results should be confirmed in larger cohorts.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Elbe, PeterDepartment of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden (author)
  • Ekheden, IsabellaDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, weden (author)
  • Wang, Qiao-LiDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston MA, USA (author)
  • Thuresson, MarcusStatisticon AB, Uppsala, Sweden (author)
  • Roelstraete, BjornDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (author)
  • Ghazi, SamDepartment of Pathology, Karolinska University Hospital, Stockholm, Sweden (author)
  • Löhr, J. -MatthiasDepartment of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden (author)
  • Ludvigsson, Jonas F.,1969-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Celiac Disease Center, Department of Medicine, Columbia University Medical Center, NY, USA; Department of Pediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden(Swepub:oru)jsln (author)
  • Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Karolinska institutet, Stockholm, SwedenDepartment of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden (creator_code:org_t)

Related titles

  • In:Scandinavian Journal of Gastroenterology: Taylor & Francis0036-55211502-7708

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view