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ARG1 expression in ...
ARG1 expression in basal forebrain microglia modulates hippocampal innervation and cognition during postnatal development
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- Venero, J. L. (author)
- Bioquímica y Biología Molecular, Facultad de Farmacia, Seville, Spain
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- Ruiz, R. (author)
- Bioquímica y Biología Molecular, Facultad de Farmacia, Seville, Spain
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- Kanatani, S. (author)
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
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- Osman, A. M. (author)
- Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
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- Keane, L. (author)
- Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden
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- Armengol, J. A. (author)
- Department of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain
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- Rodriguez-Moreno, A. (author)
- Department of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain
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- Murgoci, A. -N (author)
- Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden
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- Garcia-Dominguez, I. (author)
- Bioquímica y Biología Molecular, Facultad de Farmacia, Seville, Spain
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- Alonso-Bellido, I. (author)
- Bioquímica y Biología Molecular, Facultad de Farmacia, Seville, Spain
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- Ibañéz, F. González (author)
- Department of Molecular Medicine, Université Laval, Québec, Canada
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- Picard, K. (author)
- Department of Molecular Medicine, Université Laval, Québec, Canada
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- Vazquez-Cabrera, G. (author)
- Bioquímica y Biología Molecular, Facultad de Farmacia, Seville, Spain; Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden
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- Posada-Perez, M. (author)
- Bioquímica y Biología Molecular, Facultad de Farmacia, Seville, Spain; Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden
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- Vernoux, N. (author)
- Department of Molecular Medicine, Université Laval, Québec, Canada
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- Tejera, D. (author)
- Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Bonn, Germany
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- Grabert, K. (author)
- Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden
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- Cheray, M. (author)
- Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden
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- Gonzalez-Rodriguez, P. (author)
- Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden
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- Pérez-Villegas, E. M. (author)
- Department of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain
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- Martinéz-Gallego, I. (author)
- Department of Physiology, Anatomy and Cellular Biology, University of Pablo de Olavide, Seville, Spain
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- Lastra-Romero, A. (author)
- Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
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- Brodin, D. (author)
- Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
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- Avila-Carino, J. (author)
- Department of Molecular Biology, Umeå University, Umeå, Sweden
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- Cao, Yang, Associate Professor, 1972- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län
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- Airavaara, M. (author)
- Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
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- Uhlén, P. (author)
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
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- Heneka, M. T. (author)
- Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Bonn, Germany; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, Luxembourg
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- Tremblay, M. -È (author)
- Department of Molecular Medicine, Université Laval, Québec, Canada; Division of Medical Sciences, University of Victoria, Victoria, Canada
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- Blomgren, K. (author)
- Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
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- Stratoulias, V. (author)
- Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden; Neuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland
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- Joseph, B. (author)
- Karolinska Inst, Inst Environm Med, Toxicol Unit, Stockholm, Sweden; Institute of Environmental Medicine, Toxicology Unit, Karolinska Institutet, Stockholm, Sweden
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(creator_code:org_t)
- John Wiley & Sons, 2023
- 2023
- English.
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In: Glia. - : John Wiley & Sons. - 0894-1491 .- 1098-1136. ; 71:Suppl. 1, s. E512-E512
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- Diversity within microglia, the resident brain immune cells, is reported. Whether microglial subsets constitute different subtypes with intrinsic properties and unique functions has not been fully elucidated. Here, we describe a microglial subtype characterized by the expression of the enzyme Arginase-1, i.e.Arg1+microglia, which is found predominantly in the cholinergic neuron-rich forebrain region during early postnatal development. Arg1+microgliacontain cellular inclusions and exhibit a distinct molecular signature including upregulation of genes such as Apoe, Clec7a, Igf1, Lgals3and Mgl2. Arg1-knockout in microglia results in a deficient cholinergic innervation along with impaired dendritic spine maturation in the hippocampus where cholinergic neurons project, impaired long-term potentiation and cognitive behavioural deficiencies in female mice. Our results expand on microglia diversity and provide insights into distinctive spatiotemporal functions exerted by microglial subtypes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- vet (subject category)
- art (subject category)
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Glia
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- By the author/editor
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Venero, J. L.
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Ruiz, R.
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Kanatani, S.
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Osman, A. M.
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Keane, L.
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Armengol, J. A.
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show more...
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Rodriguez-Moreno ...
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Murgoci, A. -N
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Garcia-Dominguez ...
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Alonso-Bellido, ...
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Ibañéz, F. Gonzá ...
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Picard, K.
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Vazquez-Cabrera, ...
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Posada-Perez, M.
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Vernoux, N.
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Tejera, D.
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Grabert, K.
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Cheray, M.
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Gonzalez-Rodrigu ...
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Pérez-Villegas, ...
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Martinéz-Gallego ...
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Lastra-Romero, A ...
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Brodin, D.
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Avila-Carino, J.
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Cao, Yang, Assoc ...
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Airavaara, M.
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Uhlén, P.
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Heneka, M. T.
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Tremblay, M. -È
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Blomgren, K.
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Stratoulias, V.
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Joseph, B.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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Glia
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Örebro University