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Traumatic brain inj...
Traumatic brain injury-induced autoregulatory dysfunction and spreading depression-related neurovascular uncoupling : Pathomechanisms, perspectives, and therapeutic implications
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- Toth, Peter (author)
- Department of Neurosurgery, University of Pecs, Pecs, Hungary; Janos Szentagothai Research Centre, University of Pecs, Pecs, Hungary; Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
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- Szarka, Nicolett (author)
- Department of Neurosurgery, University of Pecs, Pecs, Hungary; Department of Translational Medicine, University of Pecs, Pecs, Hungary
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- Farkas, Eszter (author)
- Faculty of Medicine and Faculty of Science and Informatics, Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary
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- Ezer, Erzebet (author)
- Department of Neurosurgery, University of Pecs, Pecs, Hungary
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- Czeiter, Endre (author)
- Janos Szentagothai Research Centre, University of Pecs, Pecs, Hungary; Department of Neurosurgery, University of Pecs, Pecs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary
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- Amrein, Krisztina (author)
- Janos Szentagothai Research Centre, University of Pecs, Pecs, Hungary; Department of Neurosurgery, University of Pecs, Pecs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary
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- Ungvari, Zoltan (author)
- Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
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- Hartings, Jed A. (author)
- Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
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- Büki, Andras, 1966- (author)
- Janos Szentagothai Research Centre, University of Pecs, Pecs, Hungary; Department of Neurosurgery, University of Pecs, Pecs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary
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- Koller, Akos (author)
- Janos Szentagothai Research Centre, University of Pecs, Pecs, Hungary; Department of Neurosurgery, University of Pecs, Pecs, Hungary; Institute of Natural Sciences, University of Physical Education, Budapest, Hungary; Department of Physiology, New York Medical College, Valhalla, New York, United States
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(creator_code:org_t)
- HighWire Press, 2016
- 2016
- English.
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In: American Journal of Physiology. - : HighWire Press. - 0002-9513 .- 2163-5773. ; 311:5, s. H1118-H1131
- Related links:
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https://doi.org/10.1...
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https://www.physiolo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Traumatic brain injury (TBI) is a major health problem worldwide. In addition to its high mortality (35-40%), survivors are left with cognitive, behavioral, and communicative disabilities. While little can be done to reverse initial primary brain damage caused by trauma, the secondary injury of cerebral tissue due to cerebro-microvascular alterations and dysregulation of cerebral blood flow (CBF) is potentially preventable. This review focuses on functional, cellular, and molecular changes of autoregulatory function of CBF (with special focus on cerebrovascular myogenic response) that occur in cerebral circulation after TBI and explores the links between autoregulatory dysfunction, impaired myogenic response, microvascular impairment, and the development of secondary brain damage. We further provide a synthesized translational view of molecular and cellular mechanisms involved in cortical spreading depolarization-related neurovascular dysfunction, which could be targeted for the prevention or amelioration of TBI-induced secondary brain damage.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Autoregulation
- brain damage
- cerebral blood flow
- myogenic
- neurovascular coupling
Publication and Content Type
- ref (subject category)
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- By the author/editor
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Toth, Peter
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Szarka, Nicolett
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Farkas, Eszter
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Ezer, Erzebet
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Czeiter, Endre
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Amrein, Krisztin ...
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show more...
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Ungvari, Zoltan
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Hartings, Jed A.
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Büki, Andras, 19 ...
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Koller, Akos
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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American Journal ...
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American Journal ...
- By the university
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Örebro University