Prenatal exposure to environmental contaminants and cord serum metabolite profiles in future immune-mediated diseases

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Bagavathy Shanmugam, KarthikeyanSchool of Science and Technology, Örebro University, Sweden; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (author)

Prenatal exposure to environmental contaminants and cord serum metabolite profiles in future immune-mediated diseases

Article/chapterEnglish2024

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2024
Nature Publishing Group,2024
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LIBRIS-ID:oai:DiVA.org:oru-113407
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-113407URI
https://doi.org/10.1038/s41370-024-00680-zDOI

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Language:English
Summary in:English

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This work was supported by the Swedish Research Council [grant number 2020-03674; to TH], Formas [grant number 2019-00869; to TH], and by the “Inflammation in human early life: targeting impacts on life-course health” (INITIALISE) consortium funded by the Horizon Europe Program of the European Union under Grant Agreement 101094099 (to T.H., E.W.T., M.O., and J.L.). The ABIS cohort study (JL) was supported by Barndiabetesfonden (Swedish Child Diabetes Foundation), the Swedish Council for Working Life and Social Research [grant numbers FAS2004-1775 and FAS2004–1775], Swedish Research Council [Grant/Award Numbers: K2005-72 × -11242-11A and K2008-69 × -20826-01-4, K2008-69 × -20826-01-4], Östgöta Brandstodsbolag, Medical Research Council of Southeast Sweden (FORSS), JDRF Wallenberg Foundation [Grant/Award Number: K 98-99D-12813-01A], Joanna Cocozza Foundation and ALF-and LfoU grants from Region Östergötland and Linköping University, Sweden. Open access funding provided by Örebro University.
BACKGROUND: Prenatal exposure to environmental contaminants is a significant health concern because it has the potential to interfere with host metabolism, leading to adverse health effects in early childhood and later in life. Growing evidence suggests that genetic and environmental factors, as well as their interactions, play a significant role in the development of autoimmune diseases.OBJECTIVE: In this study, we hypothesized that prenatal exposure to environmental contaminants impacts cord serum metabolome and contributes to the development of autoimmune diseases.METHODS: We selected cord serum samples from All Babies in Southeast Sweden (ABIS) general population cohort, from infants who later developed one or more autoimmune-mediated and inflammatory diseases: celiac disease (CD), Crohn's disease (IBD), hypothyroidism (HT), juvenile idiopathic arthritis (JIA), and type 1 diabetes (T1D) (all cases, N = 62), along with matched controls (N = 268). Using integrated exposomics and metabolomics mass spectrometry (MS) based platforms, we determined the levels of environmental contaminants and metabolites.RESULTS: Differences in exposure levels were found between the controls and those who later developed various diseases. High contaminant exposure levels were associated with changes in metabolome, including amino acids and free fatty acids. Specifically, we identified marked associations between metabolite profiles and exposure levels of deoxynivalenol (DON), bisphenol S (BPS), and specific per- and polyfluorinated substances (PFAS).IMPACT STATEMENT: Abnormal metabolism is a common feature preceding several autoimmune and inflammatory diseases. However, few studies compared common and specific metabolic patterns preceding these diseases. Here we hypothesized that exposure to environmental contaminants impacts cord serum metabolome, which may contribute to the development of autoimmune diseases. We found differences in exposure levels between the controls and those who later developed various diseases, and importantly, on the metabolic changes associated with the exposures. High contaminant exposure levels were associated with specific changes in metabolome. Our study suggests that prenatal exposure to specific environmental contaminants alters the cord serum metabolomes, which, in turn, might increase the risk of various immune-mediated diseases.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Arbetsmedicin och miljömedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Occupational Health and Environmental Health hsv//eng
Autoimmune disease
environmental contaminants
exposome
lipidomics
metabolomics
type 1 diabetes

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Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)tihn (author)
Ghaffarzadegan, TannazSchool of Science and Technology, Örebro University, Örebro, Sweden (author)
Triplett, EricDepartment of Microbiology and Cell Science, Institute of Food and Agricultural Sciences University of Florida, Gainesville, 32611-0700, FL, USA (author)
Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, FI-20520, Finland(Swepub:oru)moc (author)
Ludvigsson, JohnnyCrown Princess Victoria's Children's Hospital and Division of Pediatrics, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, SE-581 85, Sweden (author)
School of Science and Technology, Örebro University, Sweden; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, SwedenInstitutionen för naturvetenskap och teknik (creator_code:org_t)

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In:Journal of Exposure Science and Environmental Epidemiology: Nature Publishing Group1559-06311559-064X

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