Clinical and model research of neurotrauma

Büki, Andras,1966-Department of Neurosurgery, Pécs University, Pécs, Hungary (author)

Study Protocol.
Modeling traumatic brain injury represents a major challenge for neuroscientists - to represent extremely complex pathobiological processes kept under close surveillance in the most complex organ of a laboratory animal. To ensure that such models also reflect those alterations evoked by and/or associated with traumatic brain injury (TBI) in man, well-defined, graded, simple injury paradigms should be used with clear endpoints that also enable us to assess the relevance of our findings to human observations. It is of particular importance that our endpoints should harbor clinical significance, and to this end, biological markers ultimately associated with the pathological processes operant in TBI are considered the best candidate. This chapter provides protocols for relevant experimental models of TBI and clinical materials for neuroproteomic analysis.

Kövesdi, ErzsébetDepartment of Neurosurgery, Pécs University, Pécs, Hungary (author)
Pál, JózsefDepartment of Neurosurgery, Pécs University, Pécs, Hungary (author)
Czeiter, EndreDepartment of Neurosurgery, Pécs University, Pécs, Hungary (author)
Department of Neurosurgery, Pécs University, Pécs, Hungary (creator_code:org_t)

In:Methods in Molecular BiologyTotowa, NJ : Humana Press566, s. 41-551064-37451940-6029

By the author/editor: Büki, Andras, 19 ...; Kövesdi, Erzsébe ...; Pál, József; Czeiter, Endre

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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