Search: onr:"swepub:oai:DiVA.org:oru-113423" >
A novel PARP inhibi...
A novel PARP inhibitor L-2286 in a rat model of impact acceleration head injury : an immunohistochemical and behavioral study
-
- Kövesdi, Erzsébet (author)
- Department of Neurosurgery, University of Pécs, Hungary
-
- Bukovics, Péter (author)
- Department of Neurosurgery, University of Pécs, Hungary
-
- Besson, Valérie (author)
- Laboratoire de Pharmacologie de la Circulation Cérébrale, UPRES EA 2510, Université René Descartes, Paris, France
-
show more...
-
- Nyirádi, József (author)
- Department of Neurosurgery, University of Pécs, Hungary
-
- Lückl, János (author)
- Department of Neurosurgery, University of Pécs, Hungary
-
- Pál, József (author)
- Department of Neurosurgery, University of Pécs, Hungary
-
- Sümegi, Balázs (author)
- Department of BioChemistry, University of Pécs, Pécs, Hungary
-
- Dóczi, Tamás (author)
- Department of Neurosurgery, University of Pécs, Hungary
-
- Hernádi, István (author)
- Department of Experimental Zoology and Neurobiology, University of Pécs, Hungary
-
- Büki, Andras, 1966- (author)
- Department of Neurosurgery, University of Pécs, Hungary
-
show less...
-
(creator_code:org_t)
- 2010-03-26
- 2010
- English.
-
In: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 11:4, s. 1253-1268
- Related links:
-
https://doi.org/10.3...
-
show more...
-
https://www.mdpi.com...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
show less...
Abstract
Subject headings
Close
- We examined the neuro/axono-protective potential of a novel poly (ADP-ribose) polymerase (PARP) inhibitor L-2286 in a rat impact acceleration brain injury model. Male Wistar rats (n = 70) weighing 300-350 grams were used to determine the most effective intracerebroventricular (i.c.v.) dose of L-2286 administered 30 min after injury, and to test the neuroprotective effect at two time points (immediately, and 30 min after injury). The neuroprotective effect of L-2286 was tested using immunohistochemical (amyloid precursor protein and mid-sized mouse anti-neurofilament clone RMO-14.9 antibody) and behavioral tests (beam-balance, open-field and elevated plus maze). At both time-points, a 100 microg/rat dose of i.c.v. L-2286 significantly (p < 0.05) reduced the density of damaged axons in the corticospinal tract and medial longitudinal fascicle compared to controls. In the behavioral tests, treatment 30 min post-injury improved motor function, while the level of anxiety was reduced in both treatment protocols.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- PARP-inhibitor
- impact acceleration model
- traumatic brain injury
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Kövesdi, Erzsébe ...
-
Bukovics, Péter
-
Besson, Valérie
-
Nyirádi, József
-
Lückl, János
-
Pál, József
-
show more...
-
Sümegi, Balázs
-
Dóczi, Tamás
-
Hernádi, István
-
Büki, Andras, 19 ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
International Jo ...
- By the university
-
Örebro University