Update on protein biomarkers in traumatic brain injury with emphasis on clinical use in adults and pediatrics

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Kövesdi, ErzsébetDepartment of Neurosurgery, University of Pécs, Pécs, Hungary (author)

Update on protein biomarkers in traumatic brain injury with emphasis on clinical use in adults and pediatrics

Article/chapterEnglish2010

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2009-08-04
Springer,2010
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LIBRIS-ID:oai:DiVA.org:oru-113424
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-113424URI
https://doi.org/10.1007/s00701-009-0463-6DOI

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Language:English
Summary in:English

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This work was supported by the Hungarian Science Funds (OTKA T048724/2005 and OTKA 72240).
Purpose: This review summarizes protein biomarkers in mild and severe traumatic brain injury in adults and children and presents a strategy for conducting rationally designed clinical studies on biomarkers in head trauma.Methods: We performed an electronic search of the National Library of Medicine's MEDLINE and Biomedical Library of University of Pennsylvania database in March 2008 using a search heading of traumatic head injury and protein biomarkers. The search was focused especially on protein degradation products (spectrin breakdown product, c-tau, amyloid-beta(1-42)) in the last 10 years, but recent data on "classical" markers (S-100B, neuron-specific enolase, etc.) were also examined.Results: We identified 85 articles focusing on clinical use of biomarkers; 58 articles were prospective cohort studies with injury and/or outcome assessment.Conclusions: We conclude that only S-100B in severe traumatic brain injury has consistently demonstrated the ability to predict injury and outcome in adults. The number of studies with protein degradation products is insufficient especially in the pediatric care. Cohort studies with well-defined end points and further neuroproteomic search for biomarkers in mild injury should be triggered. After critically reviewing the study designs, we found that large homogenous patient populations, consistent injury, and outcome measures prospectively determined cutoff values, and a combined use of different predictors should be considered in future studies.

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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng

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Lückl, JánosDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, United States (author)
Bukovics, PéterDepartment of Neurosurgery, University of Pécs, Pécs, Hungary; Neurobiology Research Group, Hungarian Academy of Sciences, Pécs, Hungary (author)
Farkas, OrsolyaDepartment of Neurosurgery, University of Pécs, Pécs, Hungary (author)
Pál, JózsefDepartment of Neurosurgery, University of Pécs, Pécs, Hungary (author)
Czeiter, EndreDepartment of Neurosurgery, University of Pécs, Pécs, Hungary (author)
Szellár, DóraDepartment of Neurosurgery, University of Pécs, Pécs, Hungary (author)
Dóczi, TamásDepartment of Neurosurgery, University of Pécs, Pécs, Hungary (author)
Komoly, SámuelDepartment of Neurology, University of Pécs, Pécs, Hungary (author)
Büki, Andras,1966-Department of Neurosurgery, University of Pécs, Pécs, Hungary(Swepub:oru)asbi (author)
Department of Neurosurgery, University of Pécs, Pécs, HungaryDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, United States (creator_code:org_t)

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In:Acta Neurochirurgica: Springer152:1, s. 1-170001-62680942-0940

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By the author/editor: Kövesdi, Erzsébe ...; Lückl, János; Bukovics, Péter; Farkas, Orsolya; Pál, József; Czeiter, Endre; show more...; Szellár, Dóra; Dóczi, Tamás; Komoly, Sámuel; Büki, Andras, 19 ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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