The Challenge of Mild Traumatic Brain Injury: Role of Biochemical Markers in Diagnosis of Brain Damage

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Mondello, StefaniaDepartment of Neurosciences University of Messina, Messina, Italy (author)

The Challenge of Mild Traumatic Brain Injury : Role of Biochemical Markers in Diagnosis of Brain Damage

Article/chapterEnglish2013

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2013-06-28
John Wiley & Sons,2013
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LIBRIS-ID:oai:DiVA.org:oru-113588
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-113588URI
https://doi.org/10.1002/med.21295DOI

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Language:English
Summary in:English

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Funding Agencies:Developing Competitiveness of Universities in the South Trans-Q5 danubian RegionIdentification of new biomarkers, especially, regarding the toxicity of free iron deposition in the nervous system, iron toxicity-induced oxidative stress and innate immune reactions with translational investigationsClinical Neuroscience Image Center of Hungarian Academy of Sciences (HAS)
During the past decade there has been an increasing recognition of the incidence of mildtraumatic brain injury (mTBI) and a better understanding of the subtle neurological and cognitive deficitsthat may result from it. A substantial, albeit suboptimal, effort has been made to define diagnostic criteriafor mTBI and improve diagnostic accuracy. Thus, biomarkers that can accurately and objectively detectbrain injury after mTBI and, ideally, aid in clinical management are needed. In this review, we discuss thecurrent research on serum biomarkers for mTBI including their rationale and diagnostic performances.Sensitive and specific biomarkers reflecting brain injury can provide important information regardingTBI pathophysiology and serve as candidate markers for predicting abnormal computed tomographyfindings and/or the development of residual deficits in patients who sustain an mTBI. We also outline theroles of biomarkers in settings of specific interest including pediatric TBI, sports concussions and militaryinjuries, and provide perspectives on the validation of such markers for use in the clinic. Finally, emergingproteomics-based strategies for identifying novel markers will be discussed.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
Biomarkers
traumatic brain injury
mild TBI
concussion
diagnostic

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Schmid, KaraDepartment of Applied Neurobiology, Division of Psychiatry and Neuroscience Walter Reed Army Institute of Research, Silver Spring, Maryland, United States (author)
Berger, Rachel P.Children’s Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), Safar Center forResuscitation Research, Pittsburgh, Pennsylvania, United States (author)
Kobeissy, FirasDepartment of Psychiatry, University of Florida, Gainesville, Florida, United States (author)
Italiano, DomenicoDepartment of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy (author)
Jeromin, AndreasNextGen Sciences Dx, Boston, Massachusetts, United States (author)
Hayes, Ronal L.Department of Clinical Programs, Banyan Biomarkers Inc., Alachua, Florida, United States (author)
Tortella, Frank C.Department of Applied Neurobiology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States (author)
Büki, Andras,1966-Department of Neurosurgery, University of Pecs, Pecs, Hungary; Clinical Neuroscience Image Center of Hungarian Academy of Sciences (HAS), Pecs, Hungary(Swepub:oru)asbi (author)
Department of Neurosciences University of Messina, Messina, ItalyDepartment of Applied Neurobiology, Division of Psychiatry and Neuroscience Walter Reed Army Institute of Research, Silver Spring, Maryland, United States (creator_code:org_t)

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In:Medicinal research reviews (Print): John Wiley & Sons34:3, s. 503-5310198-63251098-1128

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By the author/editor: Mondello, Stefan ...; Schmid, Kara; Berger, Rachel P ...; Kobeissy, Firas; Italiano, Domeni ...; Jeromin, Andreas; show more...; Hayes, Ronal L.; Tortella, Frank ...; Büki, Andras, 19 ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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By the university: Örebro University

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