Search: onr:"swepub:oai:DiVA.org:oru-113972" > Long noncoding RNA ...
Fältnamn | Indikatorer | Metadata |
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000 | 08610naa a2200613 4500 | |
001 | oai:DiVA.org:oru-113972 | |
003 | SwePub | |
008 | 240529s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1139722 URI |
024 | 7 | a https://doi.org/10.1073/pnas.23153631212 DOI |
040 | a (SwePub)oru | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Andrabi, Syed Bilal Ahmadu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
245 | 1 0 | a Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4+ regulatory T cells by regulating IL2RA |
264 | 1 | b Proceedings of the National Academy of Sciences (PNAS),c 2024 |
338 | a print2 rdacarrier | |
520 | a Regulatory T cells (Tregs) are central in controlling immune responses, and dysregulation of their function can lead to autoimmune disorders or cancer. Despite extensive studies on Tregs, the basis of epigenetic regulation of human Treg development and function is incompletely understood. Long intergenic noncoding RNAs (lincRNA)s are important for shaping and maintaining the epigenetic landscape in different cell types. In this study, we identified a gene on the chromosome 6p25.3 locus, encoding a lincRNA, that was up-regulated during early differentiation of human Tregs. The lincRNA regulated the expression of interleukin-2 receptor alpha (IL2RA), and we named it the lincRNA regulator of IL2RA (LIRIL2R). Through transcriptomics, epigenomics, and proteomics analysis of LIRIL2R-deficient Tregs, coupled with global profiling of LIRIL2R binding sites using chromatin isolation by RNA purification, followed by sequencing, we identified IL2RA as a target of LIRIL2R. This nuclear lincRNA binds upstream of the IL2RA locus and regulates its epigenetic landscape and transcription. CRISPR-mediated deletion of the LIRIL2R-bound region at the IL2RA locus resulted in reduced IL2RA expression. Notably, LIRIL2R deficiency led to reduced expression of Treg-signature genes (e.g., FOXP3, CTLA4, and PDCD1), upregulation of genes associated with effector T cells (e.g., SATB1 and GATA3), and loss of Treg-mediated suppression. | |
650 | 7 | a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng |
653 | a FOXP3 | |
653 | a IL2RA | |
653 | a LIRIL2R | |
653 | a long noncoding RNA | |
653 | a regulatory T cells | |
700 | 1 | a Kalim, Ubaid Ullahu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
700 | 1 | a Palani, Senthilu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
700 | 1 | a Khan, Mohd Moinu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
700 | 1 | a Khan, Meraj Hasanu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
700 | 1 | a Fagersund, Jimmyu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
700 | 1 | a Orpana, Juliusu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
700 | 1 | a Paulin, Niklasu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
700 | 1 | a Batkulwar, Kedaru Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
700 | 1 | a Junttila, Siniu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
700 | 1 | a Buchacher, Tanjau Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
700 | 1 | a Grönroos, Toniu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
700 | 1 | a Toikka, Leau Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
700 | 1 | a Ammunet, Teau Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
700 | 1 | a Sen, Parthou Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
700 | 1 | a Oresic, Matej,d 1967-u Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut0 (Swepub:oru)moc |
700 | 1 | a Kumpulainen, Venlau Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
700 | 1 | a Tuomisto, Johanna E. E.u Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
700 | 1 | a Sinha, Rahulu Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA4 aut |
700 | 1 | a Marson, Alexanderu Gladstone-University of California San Francisco Institute of Genomic Immunology, San Francisco, CA, USA4 aut |
700 | 1 | a Rasool, Omidu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut |
700 | 1 | a Elo, Laura L.u Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland; Institute of Biomedicine, University of Turku, 20520 Turku, Finland4 aut |
700 | 1 | a Lahesmaa, Riittau Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland; Institute of Biomedicine, University of Turku, 20520 Turku, Finland4 aut |
710 | 2 | a Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finlandb Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland4 org |
773 | 0 | t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciences (PNAS)g 121:23q 121:23x 0027-8424x 1091-6490 |
856 | 4 | u https://doi.org/10.1073/pnas.2315363121y Fulltext |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-113972 |
856 | 4 8 | u https://doi.org/10.1073/pnas.2315363121 |
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