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Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease
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- Salihovic, Samira, Associate Senior Lecturer, 1985- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Nyström, Niklas (author)
- Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
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- Mathisen, Charlotte Bache-Wiig (author)
- Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
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- Kruse, Robert, 1972- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Research Laboratory, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Olbjørn, Christine (author)
- Department of Pediatrics and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway
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- Andersen, Svend (author)
- Department of Pediatrics, Vestfold Hospital Trust, Tønsberg, Norway
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- Noble, Alexandra J. (author)
- Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom
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- Dorn-Rasmussen, Maria (author)
- Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
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- Bazov, Igor, 1973- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Perminow, Gøri (author)
- Department of Pediatric Medicine, Oslo University Hospital, Oslo, Norway
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- Opheim, Randi (author)
- Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
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- Detlie, Trond Espen (author)
- Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
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- Huppertz-Hauss, Gert (author)
- Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway
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- Hedin, Charlotte R. H. (author)
- Karolinska Institutet, Department of Medicine Solna, Stockholm, Sweden; Karolinska University Hospital, Gastroenterology unit, Department of Gastroenterology, Dermatovenereology and Rheumatology, Stockholm, Sweden
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- Carlson, Marie (author)
- Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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- Öhman, Lena (author)
- Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Magnusson, Maria K. (author)
- Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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- Keita, Åsa V. (author)
- Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
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- Söderholm, Johan D. (author)
- Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
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- D'Amato, Mauro (author)
- IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain; Department of Medicine & Surgery, LUM University, Casamassima, Italy
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- Oresic, Matej, 1967- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
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- Wewer, Vibeke (author)
- Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
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- Satsangi, Jack (author)
- Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom
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- Lindqvist, Carl Mårten, 1979- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Burisch, Johan (author)
- Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Gastrounit, medical division, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
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- Uhlig, Holm H. (author)
- Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom; Department of Paediatrics, University of Oxford, Oxford, UK
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- Repsilber, Dirk, 1971- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Hyötyläinen, Tuulia, 1971- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Høivik, Marte Lie (author)
- Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
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- Halfvarson, Jonas, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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(creator_code:org_t)
- Springer Nature, 2024
- 2024
- English.
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naïve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Salihovic, Samir ...
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Nyström, Niklas
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Mathisen, Charlo ...
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Kruse, Robert, 1 ...
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Olbjørn, Christi ...
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Andersen, Svend
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Noble, Alexandra ...
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Dorn-Rasmussen, ...
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Bazov, Igor, 197 ...
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Perminow, Gøri
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Opheim, Randi
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Detlie, Trond Es ...
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Huppertz-Hauss, ...
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Hedin, Charlotte ...
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Carlson, Marie
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Öhman, Lena
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Magnusson, Maria ...
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Keita, Åsa V.
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Söderholm, Johan ...
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D'Amato, Mauro
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Oresic, Matej, 1 ...
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Wewer, Vibeke
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Satsangi, Jack
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Lindqvist, Carl ...
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Burisch, Johan
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Uhlig, Holm H.
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Repsilber, Dirk, ...
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Hyötyläinen, Tuu ...
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Høivik, Marte Li ...
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Halfvarson, Jona ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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Nature Communica ...
- By the university
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Örebro University