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Belimumab concentra...
Belimumab concentration measurements using a homologous anti-idiotype immunoassay
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- Loeff, Floris C. (author)
- Biologics Laboratory, Sanquin Diagnostic Services, Amsterdam, the Netherlands
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- Parodis, Ioannis, 1981- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Gastroenterology, Dermatology and Rheumatology, Karolinska University Hospital, Stockholm, Sweden; Department of Rheumatology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Walhelm, Tomas (author)
- Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Sweden
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- Jönsen, Andreas (author)
- Department of Clinical Sciences Lund, Rheumatology, Lund University, Skåne University Hospital, Lund, Sweden
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- Nikolopoulos, Dionysis (author)
- Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Gastroenterology, Dermatology and Rheumatology, Karolinska University Hospital, Stockholm, Sweden
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- Sjöwall, Christopher (author)
- Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Sweden
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- Bengtsson, Anders A. (author)
- Department of Clinical Sciences Lund, Rheumatology, Lund University, Skåne University Hospital, Lund, Sweden
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- Kos, Dorien (author)
- Sanquin Reagents B.V., Amsterdam, the Netherlands
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- van Leeuwen, Astrid (author)
- Biologics Laboratory, Sanquin Diagnostic Services, Amsterdam, the Netherlands
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- van den Broek, Bryan (author)
- Biologics Laboratory, Sanquin Diagnostic Services, Amsterdam, the Netherlands
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- Dijk, Lisanne (author)
- Biologics Laboratory, Sanquin Diagnostic Services, Amsterdam, the Netherlands
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- Jeremiasse, Jorn (author)
- Biologics Laboratory, Sanquin Diagnostic Services, Amsterdam, the Netherlands
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- Blomjous, Birgit S. (author)
- Department of Rheumatology and Clinical Immunology, Amsterdam Rheumatology and immunology Center, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands
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- Voskuyl, Alexandre E. (author)
- Department of Rheumatology and Clinical Immunology, Amsterdam Rheumatology and immunology Center, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands
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- Wolbink, Gerrit Jan (author)
- Amsterdam Rheumatology and immunology Center|Reade, Amsterdam, the Netherlands; Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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- Bultink, Irene E. M. (author)
- Department of Rheumatology and Clinical Immunology, Amsterdam Rheumatology and immunology Center, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands
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- Rispens, Theo (author)
- Biologics Laboratory, Sanquin Diagnostic Services, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands; Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: JIM - Journal of Immunological Methods. - : Elsevier. - 0022-1759 .- 1872-7905.
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Monitoring belimumab concentrations in patients can be a valuable tool for assessing treatment response and for personalizing drug doses. Various assay formats may be used to measure concentrations of therapeutic monoclonal antibodies. A particularly useful format involves the use of anti-idiotype monoclonal antibodies, selected to be highly specific to the antibody of interest. Here, we describe the development of a specific, high-affinity anti-idiotype antibody to belimumab, and the application of this antibody in a homologous sandwich ELISA to measure belimumab concentrations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
Keyword
- Anti-idiotype antibodies
- Belimumab
- PK/ADA assays
- Rabbit monoclonal antibodies
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Loeff, Floris C.
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Parodis, Ioannis ...
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Walhelm, Tomas
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Jönsen, Andreas
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Nikolopoulos, Di ...
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Sjöwall, Christo ...
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Bengtsson, Ander ...
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Kos, Dorien
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van Leeuwen, Ast ...
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van den Broek, B ...
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Dijk, Lisanne
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Jeremiasse, Jorn
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Blomjous, Birgit ...
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Voskuyl, Alexand ...
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Wolbink, Gerrit ...
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Bultink, Irene E ...
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Rispens, Theo
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomedical Labor ...
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Örebro University