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- Ali, Magdi M. M.Stockholms universitet,Wenner-Grens institut (author)
Fc gamma RIIa (CD32) polymorphism and onchocercal skin disease : implications for the development of severe reactive onchodermatitis (ROD)
- Article/chapterEnglish2007
Publisher, publication year, extent ...
- Lawrence, Kans.American society of tropical medicine and hygiene,2007
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:oru-11541
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-11541URI
- https://doi.org/10.4269/ajtmh.2007.77.1074DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-11037URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:116331105URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-25278URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- The pathologic manifestations of Onchocerca volvulus infection depend on the interplay between the host and the parasite. A genetic single nucleotide polymorphism in the Fc gamma RIIa gene, resulting in arginine (R) or histidine (H) at position 131, affects the binding to the different IgG subclasses and may influence the clinical variations seen in onchocerciasis. This study investigated the relationship between this polymorphism and disease outcome. Fc gamma RIIa genotyping was performed on clinically characterized onchocerciasis patients (N = 100) and healthy controls (N = 74). Fc gamma RIIa genotype R/R131 frequencies were significantly higher among patients with severe dermatopathology (P < 0.001). Increased risk of developing this form was mostly associated with one tribe (Masalit) (OR = 3.2, 95% CI 1-9.9, P = 0.042). The H131 allele was found to be significantly associated with a reduced risk of having the severe form of the disease (adjusted OR = 0.26, 95% CI = 0.13-0.46, P < 0.001). Our findings suggest that the polymorphism influences the clinical outcome of onchocerciasis.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
- MEDICINE
- MEDICIN
- Clinical genetics
- Klinisk genetik
- Medicine
- Medicin
- Eye disease ; Africa ; Infection ; Parasitosis ; Helminthiasis ; Nematode disease ; Filariosis ; Sudan ; Tropical medicine ; Human ; Severe ; Disease development ; Polymorphism ; Skin disease ; Onchocerciasis ;
- Microbiology, immunology, infectious diseases
Added entries (persons, corporate bodies, meetings, titles ...)
- ElGhazali, Gehad (author)
- Montgomery, Scott M.Karolinska Institutet,Örebro universitet,Hälsoakademin(Swepub:oru)smy (author)
- Farouk, Salah E. (author)
- Nasr, Amre (author)
- Noori, Suzan I. A. (author)
- Shamad, Mahdi M. (author)
- Fadlelseed, Omar E. (author)
- Berzins, KlavsStockholms universitet,Wenner-Grens institut(Swepub:su)klavs (author)
- Tayeb, Omer (author)
- Stockholms universitetWenner-Grens institut (creator_code:org_t)
Related titles
- In:American Journal of Tropical Medicine and HygieneLawrence, Kans. : American society of tropical medicine and hygiene77:6, s. 1074-80002-96371476-1645
Internet link
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=18165525&dopt=CitationFc gamma RIIa (CD32) polymorphism and onchocercal skin disease: implications for the development of severe reactive onchodermatitis (ROD)
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-11541
- https://doi.org/10.4269/ajtmh.2007.77.1074
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-11037
- http://kipublications.ki.se/Default.aspx?queryparsed=id:116331105
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-25278
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