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Granulocyte, monocy...
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Ljung, TryggveKarolinska University Hospital
(author)
Granulocyte, monocyte/macrophage apheresis for inflammatory bowel disease : the first 100 patients treated in Scandinavia
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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2009-07-08
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Oslo :Taylor & Francis,2007
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-11569
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-11569URI
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https://doi.org/10.1080/00365520600979369DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:12311263URI
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https://lup.lub.lu.se/record/671947URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-40146URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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OBJECTIVE: Selective leukocyte apheresis is a new type of non-pharmacological treatment for patients with active ulcerative colitis and Crohn's disease. Preliminary data have indicated that this type of therapy is safe and efficacious, and large sham-controlled studies are currently in progress. In Scandinavia, a substantial number of patients with chronic inflammatory bowel disease have already received leukocyte apheresis on a compassionate use basis and the aim of this study was to report the clinical outcome and adverse events in the first patients treated. MATERIAL AND METHODS: Clinical details of the first consecutive 100 patients with inflammatory bowel disease treated with granulocyte, monocyte/macrophage (Adacolumn) apheresis in Scandinavia were prospectively registered. Median length of follow-up was 17 months, (range 5-30). RESULTS: The study population comprised 52 patients with ulcerative colitis, 44 patients with Crohn's disease and 4 patients with indeterminate colitis. In 97 patients the indication for Adacolumn treatment was steroid-refractory or steroid-dependent disease. Clinical remission was attained in 48% of the patients with ulcerative colitis, and an additional 27% had a clinical response to the apheresis treatment. The corresponding figures for patients with Crohn's disease were 41% and 23%, respectively. Complete steroid withdrawal was achieved in 27 out of the 50 patients taking corticosteroids at baseline. Adverse events were reported in 15 patients and headache was most frequently reported (n=7). CONCLUSIONS: Granulocyte, monocyte/macrophage apheresis treatment seems to be a valuable adjuvant therapy in selected patients with refractory inflammatory bowel disease. The risk for toxicity or severe adverse events appears to be low.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Thomsen, Ole Østergaard
(author)
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Vatn, MortenUniversity of Oslo
(author)
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Karlén, PerKarolinska Institutet,Soder Hospital, Stockholm
(author)
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Karlsen, Lars NormanRogaland Hospital, Stavanger
(author)
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Tysk, CurtÖrebro universitet,Hälsoakademin,Örebro University Hospital(Swepub:oru)ctk
(author)
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Nilsson, Stefan U.Kristianstad Hospital
(author)
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Kilander, AndersSahlgrenska University Hospital
(author)
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Gillberg, RolfSahlgrenska University Hospital
(author)
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Grip, OlofLund University,Lunds universitet,Enheten för kroniska inflammatoriska och degenerativa sjukdomar,Forskargrupper vid Lunds universitet,Chronic Inflammatory and Degenerative Diseases Research Unit,Lund University Research Groups,Malmö University Hospital(Swepub:lu)medf-ogr
(author)
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Lindgren, StefanLund University,Lunds universitet,Enheten för kroniska inflammatoriska och degenerativa sjukdomar,Forskargrupper vid Lunds universitet,Chronic Inflammatory and Degenerative Diseases Research Unit,Lund University Research Groups,Malmö University Hospital(Swepub:lu)medf-sli
(author)
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Befrits, RagnarKarolinska Institutet,Karolinska University Hospital
(author)
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Löfberg, RobertKarolinska Institutet,Karolinska University Hospital
(author)
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Thomsen, OOUniversity of Copenhagen
(author)
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Karolinska University HospitalUniversity of Oslo
(creator_code:org_t)
Related titles
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In:Scandinavian Journal of GastroenterologyOslo : Taylor & Francis42:2, s. 221-2270036-55211502-7708
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Ljung, Tryggve
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Thomsen, Ole Øst ...
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Vatn, Morten
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Karlén, Per
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Karlsen, Lars No ...
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Tysk, Curt
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Nilsson, Stefan ...
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Kilander, Anders
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Gillberg, Rolf
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Grip, Olof
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Lindgren, Stefan
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Befrits, Ragnar
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Löfberg, Robert
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Thomsen, OO
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Scandinavian Jou ...
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Örebro University
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Karolinska Institutet
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Linköping University