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Higher plasma but n...
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Löfgren, Christina
(author)
Higher plasma but not intracellular concentrations after infusion with liposomal daunorubicin compared with conventional daunorubicin in adult acute myeloid leukemia
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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New York :Raven P.,2007
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-11570
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-11570URI
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https://doi.org/10.1097/FTD.0b013e318156e938DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:115980650URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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To investigate the plasma and intracellular pharmacokinetics of liposomal daunorubicin (DaunoXome) in comparison with conventional daunorubicin, 14 patients aged 28 to 60 years with newly diagnosed acute myeloid leukemia were treated for 1 day with DaunoXome (50 mg/m) and for 2 days with daunorubicin (50 mg/m) with concomitant Ara-C (7 days, 200 mg/m, continuous IV). Eleven of the 14 patients entered complete remission; 9 are still alive. Pharmacokinetic profiles were obtained by blood sampling at appropriate intervals on days 1 to 4. Daunorubicin and daunorubicinol concentrations in plasma and in peripheral leukemic blast cells were measured by high-performance liquid chromatography. Following liposomal daunorubicin administration, the peak values and plasma area under the curve (AUC) were more than 100 times higher than after administration of conventional daunorubicin (AUC, 176 vs. 0.98 micromol/L x hour), but the intracellular AUCs were comparable (759 vs. 715 micromol/L x hour). Intracellular concentrations after DaunoXome peaked later and half as high as after daunorubicin. After DaunoXome versus daunorubicin, plasma clearance was 0.001 versus 0.4 micromol/h, respectively. The volume of distribution was 5.5 L for DaunoXome, versus 3640 L for daunorubicin, indicating low tissue affinity for the liposomal formulation. The authors conclude that liposomal daunorubicin, DaunoXome, yields 2-log higher plasma concentrations but similar intracellular concentrations of daunorubicin and its metabolite daunorubicinol than does free daunorubicin.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Lehmann, SörenKarolinska Institutet
(author)
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Jönsson-Videsäter, KerstinKarolinska Institutet
(author)
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Möllgård, LarsKarolinska Institutet
(author)
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Linder, Olle
(author)
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Tidefelt, UlfÖrebro universitet,Hälsoakademin(Swepub:oru)uftt
(author)
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Hassan, MoustaphaKarolinska Institutet
(author)
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Paul, ChristerKarolinska Institutet
(author)
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Karolinska InstitutetHälsoakademin
(creator_code:org_t)
Related titles
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In:Therapeutic Drug MonitoringNew York : Raven P.29:5, s. 626-6310163-43561536-3694
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