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The Medical Antiarr...
The Medical Antiarrhythmic Treatment or Radiofrequency Ablation in Paroxysmal Atrial Fibrillation (MANTRA-PAF) trial : clinical rationale, study design, and implementation
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- Jons, Christian (author)
- Gentofte University Hospital
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- Steen Hansen, Peter (author)
- Skejby University Hospital
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- Johannessen, Arne (author)
- Gentofte University Hospital
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- Hindricks, Gerhard (author)
- Leipzig University Hospital
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- Raatikainen, Pekka (author)
- Oulo University Hospital
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- Kongstad Rasmussen, Ole (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Hospital
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- Walfridsson, Håkan (author)
- Östergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken
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- Pehrson, Steen (author)
- Rigshospital
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- Almroth, Henrik (author)
- Örebro universitet,Hälsoakademin,University Hospital, Örebro
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- Hartikainen, Juha (author)
- Kuopio University Hospital
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- Petersen, Anders Kirstein (author)
- Skejby University Hospital
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- Spange Mortensen, Leif (author)
- Uni C
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- Cosedis Nielsen, Jens (author)
- Skejby University Hospital
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(creator_code:org_t)
- 2009-05-15
- 2009
- English.
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In: Europace. - : Oxford University Press (OUP). - 1099-5129 .- 1532-2092. ; 11:7, s. 917-923
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
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- AIMS: No large randomized multicentre trial has evaluated the efficacy of radiofrequency ablation (RFA) vs. anti-arrhythmic drug (AAD) therapy as a first-line treatment of paroxysmal atrial fibrillation (AF). METHODS AND RESULTS: The Medical ANtiarrhythmic Treatment or Radiofrequency Ablation (MANTRA-PAF) trial is a randomized, controlled, parallel group, multicentre study designed to test whether catheter-based RFA is superior to optimized AAD therapy in suppressing relapse within 24 months of symptomatic and/or asymptomatic AF in patients with paroxysmal AF without prior AAD therapy. The primary endpoint is cumulative AF burden on repeated 7 days Holter monitoring. Secondary endpoints are: thromboembolic events, hospitalization due to arrhythmia, pro-arrhythmic events, procedure/treatment-related side effects, health economics, quality of life, and change in left ventricular function. Ten centres in Scandinavia and Germany are participating in the study. Enrolment was started in 2005 and as of November 2008, 260 patients have been enrolled into the study. It is expected that enrolment will end by March 2009, when 300 patients have been included. CONCLUSION: The MANTRA-PAF trial will determine whether catheter-based RFA is superior to optimized AAD therapy as a first-line treatment in suppressing long-term relapse of symptomatic and/or asymptomatic AF.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
- Cardiology
- Kardiologi
- Medicine
- Medicin
- Anti-arrhythmic drugs
- Atrial fibrillation
- Radiofrequency ablation
- Randomized trial
Publication and Content Type
- ref (subject category)
- art (subject category)
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Europace
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- By the author/editor
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Jons, Christian
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Steen Hansen, Pe ...
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Johannessen, Arn ...
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Hindricks, Gerha ...
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Raatikainen, Pek ...
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Kongstad Rasmuss ...
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Walfridsson, Håk ...
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Pehrson, Steen
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Almroth, Henrik
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Hartikainen, Juh ...
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Petersen, Anders ...
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Spange Mortensen ...
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Cosedis Nielsen, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Europace
- By the university
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Örebro University
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Lund University
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Linköping University