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DNA methylation pro...
DNA methylation profiles in monozygotic and dizygotic twins
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Kaminsky, Zachary A. (author)
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Tang, Thomas (author)
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Wang, Sun-Chong (author)
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Ptak, Carolyn (author)
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Oh, Gabriel H. T. (author)
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Wong, Albert H. C. (author)
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Feldcamp, Laura A. (author)
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Virtanen, Carl (author)
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Halfvarson, Jonas, 1970- (author)
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- Tysk, Curt (author)
- Örebro universitet,Hälsoakademin
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McRae, Allan F. (author)
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Visscher, Peter M. (author)
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Montgomery, Grant W. (author)
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Gottesman, Irving I. (author)
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Martin, Nicholas G. (author)
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Petronis, Art (author)
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(creator_code:org_t)
- 2009-01-18
- 2009
- English.
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In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 41:2, s. 240-245
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Twin studies have provided the basis for genetic and epidemiological studies in human complex traits. As epigenetic factors can contribute to phenotypic outcomes, we conducted a DNA methylation analysis in white blood cells (WBC), buccal epithelial cells and gut biopsies of 114 monozygotic (MZ) twins as well as WBC and buccal epithelial cells of 80 dizygotic (DZ) twins using 12K CpG island microarrays. Here we provide the first annotation of epigenetic metastability of approximately 6,000 unique genomic regions in MZ twins. An intraclass correlation (ICC)-based comparison of matched MZ and DZ twins showed significantly higher epigenetic difference in buccal cells of DZ co-twins (P = 1.2 x 10(-294)). Although such higher epigenetic discordance in DZ twins can result from DNA sequence differences, our in silico SNP analyses and animal studies favor the hypothesis that it is due to epigenomic differences in the zygotes, suggesting that molecular mechanisms of heritability may not be limited to DNA sequence differences.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Medicin
- Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kaminsky, Zachar ...
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Tang, Thomas
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Wang, Sun-Chong
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Ptak, Carolyn
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Oh, Gabriel H. T ...
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Wong, Albert H. ...
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show more...
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Feldcamp, Laura ...
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Virtanen, Carl
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Halfvarson, Jona ...
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Tysk, Curt
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McRae, Allan F.
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Visscher, Peter ...
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Montgomery, Gran ...
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Gottesman, Irvin ...
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Martin, Nicholas ...
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Petronis, Art
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Nature Genetics
- By the university
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Örebro University