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Successful mobiliza...
Successful mobilization of Ph-negative blood stem cells with intensive chemotherapy + G-CSF in patients with chronic myelogenous leukemia in first chronic phase
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- Olsson-Strömberg, Ulla (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Hematologi
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- Höglund, Martin (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Hematologi
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- Björkholm, Magnus (author)
- Karolinska Institutet
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Braide, Inger (author)
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Carlson, Karin (author)
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- Gahrton, Gösta (author)
- Karolinska Institutet
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Grimfors, Gunnar (author)
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- Hast, Robert (author)
- Karolinska Institutet
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Lerner, Rickard (author)
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Linder, Olle (author)
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- Ljungman, Per (author)
- Karolinska Institutet
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Löfvenberg, Eva (author)
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- Malm, Claes, 1945- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Hematologiska kliniken US
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- Nilsson, Per-Gunnar (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
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- Paul, Christer (author)
- Karolinska Institutet
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Rödjer, Stig (author)
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- Stenke, Leif (author)
- Karolinska Institutet
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- Tidefelt, Ulf (author)
- Örebro universitet,Institutionen för klinisk medicin
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Turesson, Ingemar (author)
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Udén, Ann-Marie (author)
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- Wahlin, Anders (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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Vilén, Lars (author)
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Winqvist, Ingemar (author)
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Zettervall, Olle (author)
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- Öberg, Gunnar (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Hematologi
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- Simonsson, Bengt (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Hematologi
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Winqvist, Gunnar (author)
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(creator_code:org_t)
- 2009-07
- 2006
- English.
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In: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 47:9, s. 1768-73
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Abstract
Subject headings
Close
- The aim of the study was to investigate the feasibility of mobilizing Philadelphia chromosome negative (Ph-) blood stem cells (BSC) with intensive chemotherapy and lenograstim (G-CSF) in patients with CML in first chronic phase (CP1). During 1994-1999 12 centers included 37 patients <56 years. All patients received 6 months' IFN, stopping at median 36 (1-290) days prior to the mobilization chemotherapy. All received one cycle of daunorubicin 50 mg/m2 and 1 hour infusion on days 1-3, and cytarabine (ara-C) 200 mg/m2 24 hours' i.v. infusion on days 1-7 (DA) followed by G-CSF 526 microg s.c. once daily from day 8 after the start of chemotherapy. Leukaphereses were initiated when the number of CD 34+ cells was >5/microl blood. Patients mobilizing poorly could receive a 4-day cycle of chemotherapy with mitoxantrone 12 mg/m2/day and 1 hour i.v infusion, etoposide 100 mg/m2/day and 1 hour i.v. infusion and ara-C 1 g/m2/twice a day with 2 hours' i.v infusion (MEA) or a second DA, followed by G-CSF 526 microg s.c once daily from day 8 after the start of chemotherapy. Twenty-seven patients received one cycle of chemotherapy and G-CSF, whereas 10 were mobilized twice. Twenty-three patients (62%) were successfully (MNC >3.5 x 10(8)/kg, CFU-GM >1.0 x 10(4)/kg, CD34+ cells >2.0 x 10(6)/kg and no Ph+ cells in the apheresis product) [n = 16] or partially successfully (as defined above but 1-34% Ph+ cells in the apheresis product) [n = 7] mobilized. There was no mortality during the mobilization procedure. Twenty-one/23 patients subsequently underwent auto-SCT. The time with PMN <0.5 x 10(9)/l was 10 (range 7-49) and with platelets <20 x 10(9)/l was also 10 (2-173) days. There was no transplant related mortality. The estimated 5-year overall survival after auto-SCT was 68% (95% CI 47 - 90%), with a median follow-up time of 5.2 years.We conclude that in a significant proportion of patients with CML in CP 1, intensive chemotherapy combined with G-CSF mobilizes Ph- BSC sufficient for use in auto-SCT.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
- Oncology
- Onkologi
- Onkologi
- Oncology
- CML
- G-CSF
- autologous transplantation
- CML
- stem cell mobilization
- Medicin
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Olsson-Strömberg ...
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Höglund, Martin
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Björkholm, Magnu ...
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Braide, Inger
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Carlson, Karin
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Gahrton, Gösta
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show more...
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Grimfors, Gunnar
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Hast, Robert
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Lerner, Rickard
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Linder, Olle
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Ljungman, Per
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Löfvenberg, Eva
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Malm, Claes, 194 ...
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Nilsson, Per-Gun ...
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Paul, Christer
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Rödjer, Stig
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Stenke, Leif
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Tidefelt, Ulf
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Turesson, Ingema ...
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Udén, Ann-Marie
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Wahlin, Anders
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Vilén, Lars
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Winqvist, Ingema ...
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Zettervall, Olle
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Öberg, Gunnar
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Simonsson, Bengt
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Winqvist, Gunnar
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Leukemia and Lym ...
- Leuk Lymphoma
- By the university
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Örebro University
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Umeå University
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Uppsala University
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Karolinska Institutet
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Lund University
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Linköping University