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Successful mobiliza...
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Olsson-Strömberg, UllaUppsala universitet,Institutionen för medicinska vetenskaper,Hematologi
(author)
Successful mobilization of Ph-negative blood stem cells with intensive chemotherapy + G-CSF in patients with chronic myelogenous leukemia in first chronic phase
- Article/chapterEnglish2006
Publisher, publication year, extent ...
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2009-07
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Informa UK Limited,2006
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-12052
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-12052URI
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https://doi.org/10.1080/10428190600611117DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-16148URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-95820URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1940578URI
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https://lup.lub.lu.se/record/378698URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-37789URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-22582URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The aim of the study was to investigate the feasibility of mobilizing Philadelphia chromosome negative (Ph-) blood stem cells (BSC) with intensive chemotherapy and lenograstim (G-CSF) in patients with CML in first chronic phase (CP1). During 1994-1999 12 centers included 37 patients <56 years. All patients received 6 months' IFN, stopping at median 36 (1-290) days prior to the mobilization chemotherapy. All received one cycle of daunorubicin 50 mg/m2 and 1 hour infusion on days 1-3, and cytarabine (ara-C) 200 mg/m2 24 hours' i.v. infusion on days 1-7 (DA) followed by G-CSF 526 microg s.c. once daily from day 8 after the start of chemotherapy. Leukaphereses were initiated when the number of CD 34+ cells was >5/microl blood. Patients mobilizing poorly could receive a 4-day cycle of chemotherapy with mitoxantrone 12 mg/m2/day and 1 hour i.v infusion, etoposide 100 mg/m2/day and 1 hour i.v. infusion and ara-C 1 g/m2/twice a day with 2 hours' i.v infusion (MEA) or a second DA, followed by G-CSF 526 microg s.c once daily from day 8 after the start of chemotherapy. Twenty-seven patients received one cycle of chemotherapy and G-CSF, whereas 10 were mobilized twice. Twenty-three patients (62%) were successfully (MNC >3.5 x 10(8)/kg, CFU-GM >1.0 x 10(4)/kg, CD34+ cells >2.0 x 10(6)/kg and no Ph+ cells in the apheresis product) [n = 16] or partially successfully (as defined above but 1-34% Ph+ cells in the apheresis product) [n = 7] mobilized. There was no mortality during the mobilization procedure. Twenty-one/23 patients subsequently underwent auto-SCT. The time with PMN <0.5 x 10(9)/l was 10 (range 7-49) and with platelets <20 x 10(9)/l was also 10 (2-173) days. There was no transplant related mortality. The estimated 5-year overall survival after auto-SCT was 68% (95% CI 47 - 90%), with a median follow-up time of 5.2 years.We conclude that in a significant proportion of patients with CML in CP 1, intensive chemotherapy combined with G-CSF mobilizes Ph- BSC sufficient for use in auto-SCT.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Höglund, MartinUppsala universitet,Institutionen för medicinska vetenskaper,Hematologi
(author)
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Björkholm, MagnusKarolinska Institutet
(author)
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Braide, Inger
(author)
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Carlson, Karin
(author)
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Gahrton, GöstaKarolinska Institutet
(author)
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Grimfors, Gunnar
(author)
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Hast, RobertKarolinska Institutet
(author)
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Lerner, Rickard
(author)
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Linder, Olle
(author)
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Ljungman, PerKarolinska Institutet
(author)
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Löfvenberg, Eva
(author)
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Malm, Claes,1945-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Hematologiska kliniken US(Swepub:liu)clama59
(author)
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Nilsson, Per-GunnarLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-pni
(author)
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Paul, ChristerKarolinska Institutet
(author)
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Rödjer, Stig
(author)
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Stenke, LeifKarolinska Institutet
(author)
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Tidefelt, UlfÖrebro universitet,Institutionen för klinisk medicin(Swepub:oru)uftt
(author)
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Turesson, Ingemar
(author)
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Udén, Ann-Marie
(author)
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Wahlin, AndersUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)anwa0027
(author)
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Vilén, Lars
(author)
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Winqvist, Ingemar
(author)
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Zettervall, Olle
(author)
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Öberg, GunnarUppsala universitet,Institutionen för medicinska vetenskaper,Hematologi
(author)
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Simonsson, BengtUppsala universitet,Institutionen för medicinska vetenskaper,Hematologi
(author)
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Winqvist, Gunnar
(author)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Related titles
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In:Leukemia and Lymphoma: Informa UK Limited47:9, s. 1768-731042-81941029-2403
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In:Leuk Lymphoma: Informa UK Limited47:9, s. 1768-73
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Olsson-Strömberg ...
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Höglund, Martin
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Björkholm, Magnu ...
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Braide, Inger
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Carlson, Karin
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Gahrton, Gösta
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Grimfors, Gunnar
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Hast, Robert
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Lerner, Rickard
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Linder, Olle
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Ljungman, Per
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Löfvenberg, Eva
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Malm, Claes, 194 ...
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Nilsson, Per-Gun ...
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Paul, Christer
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Rödjer, Stig
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Stenke, Leif
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Tidefelt, Ulf
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Turesson, Ingema ...
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Udén, Ann-Marie
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Wahlin, Anders
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Vilén, Lars
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Winqvist, Ingema ...
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Zettervall, Olle
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Öberg, Gunnar
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Simonsson, Bengt
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Winqvist, Gunnar
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Cancer and Oncol ...
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Leukemia and Lym ...
- Leuk Lymphoma
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Örebro University
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Umeå University
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Uppsala University
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Karolinska Institutet
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Lund University
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Linköping University